COPA and SACM1L

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		COPA	SACM1L
Description		COPI coat complex subunit alpha	SAC1 like phosphatidylinositide phosphatase
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane COPI Vesicle Coat Transport Vesicle Growth Cone Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	Hormone Activity Structural Molecule Activity Protein Binding	Phosphatidylinositol-3-phosphatase Activity Protein Binding Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Signal Transduction Pancreatic Juice Secretion	Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Dephosphorylation
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane
Drugs
Diseases
GWAS		Breast size ( 27182965)	Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Response to anti-depressant treatment in major depressive disorder ( 22041458) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: ARCN1 ARFGAP1 CDC42 COPB2 COPE DUX4 MTNR1B PDGFRB PTEN SACM1L SCYL1 SLC25A11 STX8 SUMO2 TMED10 TMED2 WBP1 WBP2	35 interacting genes: ACKR2 AQP6 ARL13B CD79A COPA COPB2 COPG1 CREB3 CREB3L1 DHRS7 EBP FFAR2 FMO3 GPR151 GPR152 HSD17B13 JAGN1 LMNA MFF MFSD14B MTERF2 ODF4 PRKCA RNF19B RTN3 SCN3B SLC10A1 SLC10A6 SLC35A5 SLC35C2 SLC7A1 TMEM167B TMX2 VEZT ZFYVE27
Entrez ID		1314	22908
HPRD ID		03564	07587
Ensembl ID		ENSG00000122218	ENSG00000211456
Uniprot IDs		P53621	B4DVV3 E9PGZ4 Q9NTJ5
PDB IDs		6PBG 6TZT 6U3V
Enriched GO Terms of Interacting Partners?
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