DNAJC19 and SHANK2

Data Source:
BioGRID (affinity chromatography technology)

		DNAJC19	SHANK2
Description		DnaJ heat shock protein family (Hsp40) member C19	SH3 and multiple ankyrin repeat domains 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	PAM Complex, Tim23 Associated Import Motor Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane Protein-containing Complex Inner Mitochondrial Membrane Protein Complex Matrix Side Of Mitochondrial Inner Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	ATPase Activator Activity Protein Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Protein Folding Protein Targeting To Mitochondrion Visual Perception Protein Import Into Mitochondrial Matrix Positive Regulation Of ATPase Activity Genitalia Development Regulation Of Cardiolipin Metabolic Process	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Mitochondrial protein import	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases		3-Methylglutaconic aciduria (MGCA)
GWAS		Schizophrenia ( 28991256 25056061 29483656 30285260)	Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		4 interacting genes: APP HSPA9 MCPH1 PAM16	19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		131118	22941
HPRD ID		12349	04479
Ensembl ID		ENSG00000205981	ENSG00000162105
Uniprot IDs		A0A0S2Z5X1 Q96DA6	A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8
PDB IDs
Enriched GO Terms of Interacting Partners?
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