COL11A2 and ANXA7

Data Source:
BioGRID (two hybrid)

		COL11A2	ANXA7
Description		collagen type XI alpha 2 chain	annexin A7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type XI Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Membrane Chromaffin Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Metal Ion Binding	RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Calcium-dependent Protein Binding
	Biological Process	Skeletal System Development Sensory Perception Of Sound Extracellular Matrix Organization Collagen Fibril Organization Cartilage Development Roof Of Mouth Development Soft Palate Development	Autophagy Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Epithelial Cell Differentiation Response To Calcium Ion Membrane Fusion
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization
Drugs
Diseases		Ossification of the posterior longitudinal ligament of spine (OPLL) Deafness, autosomal dominant Type XI collagenopathies, including: Stickler syndrome type 2; Stickler syndrome type 3; Otospondylomegaepiphyseal dysplasia (OSMED); Marshall syndrome; Weissenbacher-Zweymuller syndrome Deafness, autosomal recessive
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 29875488) Height ( 31217584) Lung cancer ( 28604730) Rosacea symptom severity ( 29771307) SjÃ¶gren's syndrome ( 24097066) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Wegener's granulomatosis ( 23740775)	Copper levels ( 26025379)
Interacting Genes		3 interacting genes: ANXA7 PIN1 TK1	107 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 ANGPT2 APC APLP1 ATP5F1B ATP6V1A ATXN3 BAG6 CCDC90B CCT7 CDK4 CELF3 CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE2 CPNE6 CRMP1 CSAD CTSB DDAH2 DMPK DOCK7 DVL1 DYNC1I1 EEF1A1 ERG28 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GAPDH GBP2 GDF9 GNB2 GNB5 HADHB HMGXB3 HOXD8 INPP5K INTS11 KLHL23 KMT2B LRIF1 MED31 MPPED1 MSH2 NGFR NMT2 NPRL2 OTUB1 PAAF1 PAX8 PDCD6 PDHB PKM PLD3 PRKACA PRKCA PRKCB PRKCG PRKG1 PSMB10 QARS1 RBBP4 RBM48 RPA1 RPL13 RPS2 S100A10 SDF4 SEMA5B SETDB1 SMPD1 SP110 SRC SRI SUMO3 TAF5L TIAM2 TLE1 TMEM108 TMSB4X TRMT2A TUBA1A TUBB2B TUBB3 UBE2D1 UCHL5 UNC119 USP4 VIM WDR18 WDR73 ZBTB16 ZNF135 ZNF431
Entrez ID		1302	310
HPRD ID		00376	01720
Ensembl ID		ENSG00000204248	ENSG00000138279
Uniprot IDs		A0A0C4DFS1 H0YIS1 P13942 Q4VXY6	B2R657 P20073
PDB IDs
Enriched GO Terms of Interacting Partners?
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