BBS5 and CRADD

Data Source:
BioGRID (two hybrid)

		BBS5	CRADD
Description		Bardet-Biedl syndrome 5	CASP2 and RIPK1 domain containing adaptor with death domain
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GO Annotations	Cellular Component	Cytosol Axoneme Centriolar Satellite BBSome Ciliary Basal Body Ciliary Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding Phosphatidylinositol-3-phosphate Binding	Protease Binding Protein Binding Protein-macromolecule Adaptor Activity Death Domain Binding
	Biological Process	Heart Looping Visual Perception Protein Transport Melanosome Transport Motile Cilium Assembly Intracellular Transport Response To Stimulus Cilium Assembly	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway
Pathways		BBSome-mediated cargo-targeting to cilium	TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Iris heterochromicity ( 30895295)	Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 31959851) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 25282103 31562340 18391951 31217584) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30061609 30804560) Pulse pressure ( 27841878) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Reticulocyte count ( 32888494)
Interacting Genes		2 interacting genes: CRADD KLC3	22 interacting genes: ACTN2 APP APPL2 BBS5 CASP2 CASP8 CCSER2 DCXR EEF1A1 ERG28 IL9R KCTD9 KPNA1 LRIF1 PIDD1 PTGER4 RIPK1 SLC35A3 TRIM54 TSHR VTN WIF1
Entrez ID		129880	8738
HPRD ID		10353	04584
Ensembl ID		ENSG00000163093	ENSG00000169372
Uniprot IDs		A0A0S2Z626 Q8N3I7	B4DJT6 F5H7C2 F8VV49 F8VVY5 P78560 Q53XL1 Q8IY43
PDB IDs		6XTB	2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?
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