TMEM18 and RETREG3

Data Source:
BioGRID (two hybrid)

		TMEM18	RETREG3
Description		transmembrane protein 18	reticulophagy regulator family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Integral Component Of Membrane Nuclear Membrane	Integral Component Of Membrane Protein-containing Complex
	Molecular Function	DNA Binding	Protein Binding
	Biological Process	Cell Migration	Positive Regulation Of Neuron Projection Development Reticulophagy
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat percentage ( 26833246) Body mass index ( 28552196 29381148 24064335 23563607 26426971 19079260 19079261 26961502 23669352 24861553 31453325 28892062 25673413 20935630 28448500) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast size ( 27182965) C-reactive protein levels ( 30388399) Childhood body mass index ( 33045005 26604143) Coffee consumption ( 31046077) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Heschl's gyrus morphology ( 25130324) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Menarche (age at onset) ( 27182965 21102462 25231870) Metabolic syndrome ( 31589552) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (early onset extreme) ( 20421936 23563609) Obesity (extreme) ( 30677029) Obesity-related traits ( 23251661) Parental lifespan ( 30642433) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Refractive error ( 32231278) Response to fenofibrate (adiponectin levels) ( 23149075) Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) ( 24503447) Serum uric acid levels ( 30993211) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 24509480 30054458 30297969 32499647 30718926 28869590) Urate levels ( 31578528) Uric acid levels ( 22229870) Waist circumference ( 28552196 31453325 25673412) Waist circumference variance ( 31453325) Weight ( 28552196 19079260)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		2 interacting genes: REEP4 RETREG3	109 interacting genes: ABHD16A ACSL5 AGPAT4 AGTRAP ANKRD46 ARL6IP1 ARPC3 ATP6V0C BET1 BNIP1 C16orf92 C1GALT1 C4orf3 CCDC167 CCL4L2 CDIPT CDS1 CLCA4 CMTM3 CMTM5 CMTM7 CSGALNACT2 CYB5B CYP4F2 DERL1 DHRSX ERG28 FAXDC2 FKBP8 FUNDC2 GABARAPL1 GABARAPL2 GIMAP5 GOSR2 HMOX2 HTATIP2 IFITM3 JAGN1 LEMD1 LPAR3 LPCAT2 LRCH4 MAL2 MALL MAP1LC3A MCRS1 MFF MOB2 MOSPD3 NRM ORMDL2 ORMDL3 OTULINL PKMYT1 PLP2 PLPP6 PNLIPRP1 PRAF2 RABAC1 REEP6 RUSF1 SCD SEC22A SENP2 SERP2 SFT2D1 SFXN3 SLC30A3 SLC39A6 SMCO4 SMIM1 STAP1 STX5 STX7 STX8 SYNGR1 TBRG4 TCEA2 TECR TMEM100 TMEM11 TMEM120B TMEM128 TMEM176A TMEM18 TMEM203 TMEM218 TMEM222 TMEM237 TMEM239 TMEM243 TMEM254 TMEM31 TMEM42 TMEM60 TMEM65 TMPPE TPRG1 TSNARE1 TSPO2 UBIAD1 VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB YIPF1 YIPF6
Entrez ID		129787	162427
HPRD ID		15529	14108
Ensembl ID		ENSG00000151353	ENSG00000141699
Uniprot IDs		Q96B42	K7EQI9 Q86VR2
PDB IDs
Enriched GO Terms of Interacting Partners?
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