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LRRC25 and ACD
Data Source:
BioGRID
(two hybrid)
LRRC25
ACD
Description
leucine rich repeat containing 25
ACD shelterin complex subunit and telomerase recruitment factor
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Integral Component Of Membrane
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleoplasm
Telomerase Holoenzyme Complex
Nuclear Body
Shelterin Complex
Molecular Function
Protein Binding
Protein Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Biological Process
Telomere Maintenance
Intracellular Protein Transport
Telomere Maintenance Via Telomerase
Telomere Capping
Protection From Non-homologous End Joining At Telomere
Telomere Assembly
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Telomerase Activity
Positive Regulation Of Single-stranded Telomeric DNA Binding
Protein Localization To Chromosome, Telomeric Region
Establishment Of Protein Localization To Telomere
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Body size at age 10 (
32376654
)
Hyperemesis gravidarum (
29563502
)
Monocyte percentage of white cells (
32888494
27863252
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Systemic lupus erythematosus (
33536424
28714469
)
White blood cell count (
32888494
)
Hemoglobin levels (
32327693
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
38 interacting genes:
ACD
AGPAT4
ANKRD46
APOL3
ATP6V0C
BMP10
BRICD5
C3orf52
CD72
CLDN19
CLEC1A
CLN6
CLRN2
CNIH3
CXCL9
DEFB121
DNAJC30
EDDM3B
FAM3C
FATE1
FPR2
GPRC5D
LHFPL5
MAL
OPRM1
PKMYT1
PNLIPRP1
SEC22A
SEC61G
SMCO4
SPNS3
TMEM120A
TMEM201
TNF
TRAF3IP3
TSPAN4
VAMP5
YIPF6
63 interacting genes:
ACTB
ADPRH
AFAP1L2
AIPL1
ANKMY2
ANXA8L1
APOBEC3F
BAG3
CKB
CTTN
DBN1
DBNL
DCX
DPYSL3
EIF3G
EIF4B
ENO2
ENSA
FAM131B
FKBP6
GAPDH
HSP90AB1
IPO5
IVL
LASP1
LDHA
LGALSL
LLGL1
LRRC25
NCDN
NTAQ1
NUDC
NUDCD2
PAGE2
PDLIM2
PEX5
PFKP
PGM2
POT1
RBKS
RECQL4
RGS3
RPSA
SBDS
STIP1
STUB1
SULT1C2
TAGLN
TBC1D10A
TBCD
TINF2
TOMM34
TRIM15
TRIM16
TRIM55
TRIM63
TUBB2A
TUBB4B
USP7
XRCC6
YWHAE
ZFP36L1
ZNF790
Entrez ID
126364
65057
HPRD ID
09597
12417
Ensembl ID
ENSG00000175489
ENSG00000102977
Uniprot IDs
Q8N386
A0A590TQL1
Q96AP0
PDB IDs
2I46
5H65
5I2X
5I2Y
5UN7
5XYF
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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