FRMD6 and TLK2

Data Source:
BioGRID (two hybrid)

		FRMD6	TLK2
Description		FERM domain containing 6	tousled like kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Actomyosin Structure Organization	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Anticoagulant levels ( 22216198) Brain structure ( 20171287) Cognitive decline rate in late mild cognitive impairment ( 26252872) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hippocampal atrophy ( 19668339) Lung cancer (smoking interaction) ( 24658283) Multiple sclerosis ( 31604244) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Total ventricular volume ( 21116278) Triglyceride levels x loop diuretics use interaction ( 31806883)	Heel bone mineral density ( 30598549) Lifespan ( 25918517)
Interacting Genes		27 interacting genes: - BLZF1 COX6B2 DNAJA3 EXOC5 GMCL1 HMBOX1 IKZF1 JMJD6 LZTS2 MAK16 MED4 MID2 MLH1 NKAPD1 PARD6B RASSF8 SSX2IP SUV39H1 SYT17 TCF12 TLK2 TRIM55 TRIM63 TSC22D4 WDR7 YWHAB	17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ
Entrez ID		122786	11011
HPRD ID		12646	10527
Ensembl ID		ENSG00000139926	ENSG00000146872
Uniprot IDs		Q96NE9	B4DUC2 J3QLK5 Q86UE8
PDB IDs			5O0Y
Enriched GO Terms of Interacting Partners?
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