CMA1 and KITLG

Data Source:
HPRD (in vitro)

		CMA1	KITLG
Description		chymase 1	KIT ligand
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Cytoplasmic Ribonucleoprotein Granule Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Cytoplasm Cytoskeleton Plasma Membrane Integral Component Of Membrane Lamellipodium Filopodium
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptide Binding	Cytokine Activity Stem Cell Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Angiotensin Maturation Extracellular Matrix Disassembly Midbrain Development Basement Membrane Disassembly Positive Regulation Of Angiogenesis Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus Cytokine Precursor Processing	MAPK Cascade Ovarian Follicle Development Neural Crest Cell Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of Myeloid Leukocyte Differentiation Cell Adhesion Positive Regulation Of Cell Population Proliferation Male Gonad Development Negative Regulation Of Mast Cell Apoptotic Process Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Positive Regulation Of MAP Kinase Activity Positive Regulation Of Melanocyte Differentiation Positive Regulation Of Ras Protein Signal Transduction Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mast Cell Proliferation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Signaling by SCF-KIT Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins
Drugs		Benzylsulfonic acid 2-(N-morpholino)ethanesulfonic acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases			Familial progressive hyperpigmentation
GWAS			Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Hair color ( 23548203 29662168) Light vs. dark hair color ( 26184321) Mean corpuscular volume ( 32888494) Nevus count ( 30429480) Red blood cell traits ( 23222517) Testicular cancer ( 19483682) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		10 interacting genes: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3	8 interacting genes: CLEC11A CMA1 CSF2 EPOR FLT3LG KIT PIK3CD UBE2V1
Entrez ID		1215	4254
HPRD ID		00346	01698
Ensembl ID		ENSG00000092009	ENSG00000049130
Uniprot IDs		P23946 Q4FEB3	A0A024RBC0 A0A024RBF5 P21583
PDB IDs		1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0 5YJM 5YJP	1EXZ 1SCF 2E9W
Enriched GO Terms of Interacting Partners?
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