ZFYVE27 and STX7

Data Source:
BioGRID (two hybrid)

		ZFYVE27	STX7
Description		zinc finger FYVE-type containing 27	syntaxin 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Cytosol Integral Component Of Endoplasmic Reticulum Membrane Axon Dendrite Growth Cone Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Endoplasmic Reticulum Tubular Network	Immunological Synapse Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Endocytic Vesicle SNARE Complex Early Endosome Membrane Vesicle Azurophil Granule Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Tertiary Granule
	Molecular Function	Protein Binding Identical Protein Binding Protein Self-association Metal Ion Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding
	Biological Process	Vesicle-mediated Transport Neuron Projection Development Positive Regulation Of Axon Extension Neurotrophin TRK Receptor Signaling Pathway Endoplasmic Reticulum Tubular Network Formation Protein Localization To Plasma Membrane	Positive Regulation Of T Cell Mediated Cytotoxicity Intracellular Protein Transport Vesicle Fusion Vesicle Docking Organelle Localization Organelle Assembly Positive Regulation Of Receptor Localization To Synapse Regulation Of Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		18 interacting genes: APP GIMAP1 GIMAP5 IER3IP1 ORMDL1 OTOP3 PIP4P2 SACM1L SEC22A SLC30A8 SLC66A2 STX7 TMEM128 TMEM14C TMEM243 TMEM65 TSPAN2 YIF1A	54 interacting genes: ANKS6 AQP6 ARL13B CERS4 CISD2 CREB3 CREB3L1 CYBRD1 DNAJC5 EBP ELOVL5 ENTPD2 FAM174A FAM210B FKBP7 GJC3 HSD17B11 HSD17B13 JAGN1 LIME1 LMNA LSMEM2 MAPK6 MFF MGST3 MRM1 MTUS1 NAPA REEP1 RETREG3 RIC3 SAR1A SLC10A1 SLC10A6 SNAP29 STX1A STX2 STX4 STX6 STX8 TM4SF19 TMEM205 TMEM241 TMEM267 TMEM80 TMPRSS2 TMX2 VAMP7 VAMP8 VPS11 VPS16 VPS18 VTI1B ZFYVE27
Entrez ID		118813	8417
HPRD ID		15735	04449
Ensembl ID		ENSG00000155256	ENSG00000079950
Uniprot IDs		A0A0S2Z627 B7Z6J9 Q5T4F4	O15400
PDB IDs		1X4U
Enriched GO Terms of Interacting Partners?
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