ATXN3L and KLF5

Data Source:
BioGRID (enzymatic study)

		ATXN3L	KLF5
Description		ataxin 3 like	Kruppel like factor 5
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GO Annotations	Cellular Component	Nucleus Cytosol	Chromatin Nucleoplasm Transcription Regulator Complex Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding MRF Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Skeletal Muscle Satellite Cell Differentiation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Microvillus Assembly Regulation Of Microvillus Assembly Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Cell Development Positive Regulation Of Transcription By Transcription Factor Localization Cellular Response To Organic Cyclic Compound Cell-cell Signaling Via Exosome Cellular Response To Peptide Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor
Pathways		Josephin domain DUBs	Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29679657) Blood urea nitrogen levels ( 31152163) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chronotype ( 30696823) Colorectal cancer ( 30529582) Colorectal cancer or advanced adenoma ( 30510241) Creatine kinase levels ( 29403010) Endometrial cancer ( 30093612 27008869) Endometrial cancer (endometrioid histology) ( 30093612) Intraocular pressure ( 29785010 31959993) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Pancreatic cancer ( 29422604 20101243 26098869 25086665) Prostate cancer ( 31562322 26443449) Systolic blood pressure ( 30224653) Type 2 diabetes ( 25760438)
Interacting Genes		8 interacting genes: KLF5 PJA1 RFFL TRIM54 TRIM55 TRIM63 UBC USP28	27 interacting genes: ANP32B ATXN3L BAP1 CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F2 HDAC1 JUN NCOR1 NCOR2 NFKB1 PARP1 PPARG PRKCA PRKCD RARA RXRA SET SMURF2 TBP UBE2I WWP1
Entrez ID		92552	688
HPRD ID		19697	04212
Ensembl ID		ENSG00000123594	ENSG00000102554
Uniprot IDs		B4DYC7 Q9H3M9	Q13887 Q5T6X2
PDB IDs		3O65	2EBT
Enriched GO Terms of Interacting Partners?
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