GUCY1B1 and GUCY1A2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		GUCY1B1	GUCY1A2
Description		guanylate cyclase 1 soluble subunit beta 1	guanylate cyclase 1 soluble subunit alpha 2
Image			No pdb structure
GO Annotations	Cellular Component	Guanylate Cyclase Complex, Soluble Presynaptic Active Zone	Cytoplasm
	Molecular Function	Guanylate Cyclase Activity Protein Binding GTP Binding Heme Binding Signaling Receptor Activity Metal Ion Binding	Guanylate Cyclase Activity Protein Binding GTP Binding Heme Binding Protein-containing Complex Binding
	Biological Process	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation CGMP-mediated Signaling Nitric Oxide-cGMP-mediated Signaling Pathway Cellular Response To Nitric Oxide Trans-synaptic Signaling By Nitric Oxide, Modulating Synaptic Transmission	CGMP Biosynthetic Process Signal Transduction Positive Regulation Of Nitric Oxide Mediated Signal Transduction Intracellular Signal Transduction
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction	Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction
Drugs			Nitric Oxide Isosorbide mononitrate Riociguat Methylene blue Molsidomine Plecanatide
Diseases
GWAS			Anxiety disorder ( 25390645) Colorectal or endometrial cancer ( 26621817) Diastolic blood pressure ( 27841878) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Upper eyelid morphology ( 29921221) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Whole brain grey matter density ( 31530798)
Interacting Genes		4 interacting genes: AGAP1 APP GUCY1A2 HSP90AA1	9 interacting genes: DLG1 DLG2 DLG3 DLG4 ERBIN GSC2 GUCY1B1 SNTA1 STUB1
Entrez ID		2983	2977
HPRD ID		00769	03146
Ensembl ID		ENSG00000061918	ENSG00000152402
Uniprot IDs		B7Z685 B7Z6G8 B7Z9H9 D6RC99 E9PCN2 Q02153	P33402
PDB IDs		2WZ1 3UVJ 4NI2 5MNW 6JT0 6JT1 6JT2
Enriched GO Terms of Interacting Partners?
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