CLNK and WWOX

  • Data Source:
  • BioGRID (two hybrid)

CLNK

WWOX

Description cytokine dependent hematopoietic cell linker WW domain containing oxidoreductase
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289)
  • Alzheimer's disease (late onset) ( 30820047)
  • Anorexia nervosa ( 23568457)
  • Bipolar disorder (body mass index interaction) ( 24322204)
  • Brain morphology (MOSTest) ( 32665545)
  • Brain volume in infants (white matter) ( 28763065)
  • Cardiac structure and function ( 19584346)
  • Clozapine-induced cytotoxicity ( 25656473)
  • Colorectal cancer ( 30529582 29228715)
  • Daytime sleep phenotypes ( 27126917)
  • Diffusing capacity of carbon monoxide ( 30694715)
  • Early-onset Parkinson's disease ( 28256260)
  • Eosinophil counts ( 32888494)
  • Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678)
  • Familial squamous cell lung carcinoma ( 29924316)
  • FEV1 ( 30804560)
  • Gut microbiota relative abundance (Faecalibacterium) ( 33208821)
  • Hematocrit ( 32888494)
  • Hemoglobin ( 32888494)
  • Hip shape (DXA scan) ( 30320955)
  • Idiopathic dilated cardiomyopathy ( 29495422)
  • Lung function (forced vital capacity) ( 24929828)
  • Lung function (FVC) ( 30804560)
  • Lymphocyte counts ( 32888494)
  • Macular thickness ( 30535121)
  • Metabolite levels ( 23823483)
  • Metabolite levels (5-HIAA) ( 23319000)
  • Molybdenum levels ( 26025379)
  • Monocyte count ( 32888494)
  • Multiple sclerosis ( 31604244 24076602)
  • Obesity ( 21552555)
  • Paclitaxel disposition in epithelial ovarian cancer ( 29367611)
  • Peak expiratory flow ( 30804560)
  • Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954)
  • Platelet count ( 32888494)
  • Plateletcrit ( 32888494)
  • Post bronchodilator FEV1/FVC ratio ( 26634245)
  • Pulmonary function ( 21946350)
  • Pulmonary function (smoking interaction) ( 23284291)
  • Radiation response ( 20923822)
  • Red blood cell count ( 32888494)
  • Refractive error ( 32231278)
  • Response to amphetamines ( 22952603)
  • Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309)
  • Response to fenofibrate (HDL cholesterol levels) ( 27002377)
  • Serum thyroid-stimulating hormone levels ( 25436638)
  • Serum uric acid levels in response to allopurinol in gout ( 25676789)
  • Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)
  • Systemic juvenile idiopathic arthritis ( 27927641)
  • Type 2 diabetes ( 22158537)
  • Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes 29 interacting genes: ANKRD50 ARAP3 BMX COQ9 CRK CYB561D2 EGFR ERBB2 FAM217A GLIS3 GRB2 GSTCD LCP2 NME4 P4HA2 PACSIN3 PIK3R1 PIK3R3 PPP1R7 PTK7 RASSF1 RB1 RPAIN SFMBT1 SMARCD1 SOCS6 STK36 TXK WWOX 116 interacting genes: ABHD11 ABI2 ACAT2 ACY1 ADRA2C ANAPC11 ANXA11 APBB2 ARRDC3 C10orf55 C11orf87 C19orf54 CCDC24 CEACAM6 CLNK CNNM3 CPSF2 CPSF6 CPSF7 CREB5 CSNK2B CTAG1A CTAG1B CTDSP1 DAZAP2 DMRT3 ENKD1 ERBB4 EZR FAM214B FAM222B FEM1A FIP1L1 FOXD4L1 FOXI1 FRS3 GCM2 GEM GLIS2 GNE HNRNPK HOXA1 HOXC8 HSPB2 HSPB2-C11orf52 HYAL2 IFIT2 INCA1 KLHDC7B KLHL38 KRT3 KRT34 KRT75 KRTAP11-1 LASP1 LATS1 LITAF LMO3 MAPK8 MED25 MKRN3 MYG1 MYOZ1 MYOZ2 NEDD9 NUDT21 OLIG3 OTX1 PATL1 PATZ1 PAX9 PBX4 PEF1 PITX2 PLAC8 PLEKHN1 PLSCR3 PPP1R32 PSMB8 RAMAC RUSC1 SAXO1 SCAMP3 SEC23IP SF3B3 SH2D4A SHC3 SLC15A2 SMAD4 SMR3A SNRPC SRC TCERG1 TCHP TEKT3 TEX37 TFAP2C TFG TNK2 TP53 TP73 TRIM69 TSGA10IP UBB UFSP1 VENTX VEZF1 VPS37C WDR33 WIPF2 YPEL3 ZBTB32 ZIC1 ZNF135 ZNF414 ZNF581
Entrez ID 116449 51741
HPRD ID 14720 05501
Ensembl ID ENSG00000109684 ENSG00000186153
Uniprot IDs Q7Z7G1 A0A411HBC7 Q9NZC7
PDB IDs 1WMV
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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