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IL3RA and CSF2
Data Source:
HPRD
(in vitro)
IL3RA
CSF2
Description
interleukin 3 receptor subunit alpha
colony stimulating factor 2
Image
GO Annotations
Cellular Component
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Receptor Complex
Extracellular Region
Extracellular Space
Intracellular Membrane-bounded Organelle
Molecular Function
Cytokine Receptor Activity
Interleukin-3 Receptor Activity
Protein Binding
Cytokine Binding
Cytokine Activity
Granulocyte Macrophage Colony-stimulating Factor Receptor Binding
Protein Binding
Growth Factor Activity
Biological Process
MAPK Cascade
Cytokine-mediated Signaling Pathway
Cellular Response To Interleukin-3
Interleukin-3-mediated Signaling Pathway
MAPK Cascade
Histamine Secretion
Embryonic Placenta Development
Immune Response
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Cytokine-mediated Signaling Pathway
Myeloid Cell Differentiation
Neutrophil Differentiation
Monocyte Differentiation
Macrophage Differentiation
Positive Regulation Of Interleukin-23 Production
Response To Silicon Dioxide
Response To Fluid Shear Stress
Epithelial Fluid Transport
Macrophage Activation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Myeloid Dendritic Cell Differentiation
Regulation Of Circadian Sleep/wake Cycle, Sleep
Regulation Of Myeloid Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Cellular Response To Lipopolysaccharide
Positive Regulation Of Podosome Assembly
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Dendritic Cell Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
Interleukin-10 signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Interleukin receptor SHC signaling
Drugs
Sargramostim
Tagraxofusp
KB002
Diseases
GWAS
Schizophrenia (
17522711
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
23128233
)
Rheumatoid arthritis (
30423114
22446963
24390342
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Interacting Genes
32 interacting genes:
BMP10
C2CD2L
CDC25A
CDK1
CISH
CLDN19
CSF2
CSF2RB
EMP3
FOXP1
GIMAP1
GNA12
IL3
JAGN1
JAK1
JAK2
LNX1
NINJ2
NR0B2
PAQR5
PPP1CC
SAE1
SERP1
SGK2
SMAGP
SYS1
TMEM128
TMEM147
TMEM254
TMEM65
TRARG1
VAMP5
7 interacting genes:
CSF2RA
CSF2RB
IL3RA
KITLG
MEOX2
PRG2
SDC2
Entrez ID
3563
1437
HPRD ID
02392
00734
Ensembl ID
ENSG00000185291
ENSG00000164400
Uniprot IDs
P26951
P04141
PDB IDs
4JZJ
5UV8
5UWC
6NMY
1CSG
2GMF
4NKQ
4RS1
5C7X
5D70
5D71
5D72
6BFQ
6BFS
Enriched GO Terms of Interacting Partners
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