CHRNB4 and CHRNA3

Data Source:
HPRD (in vitro)

		CHRNB4	CHRNA3
Description		cholinergic receptor nicotinic beta 4 subunit	cholinergic receptor nicotinic alpha 3 subunit
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Specific Granule Membrane Neuron Projection Synapse Postsynaptic Membrane Tertiary Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Postsynaptic Density Integral Component Of Membrane Dendrite Neuron Projection Neuronal Cell Body Plasma Membrane Raft Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Protein-containing Complex Binding	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding
	Biological Process	Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Regulation Of Membrane Potential Neutrophil Degranulation Regulation Of Neurotransmitter Secretion Nervous System Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition	Ion Transport Regulation Of Smooth Muscle Contraction Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Locomotory Behavior Regulation Of Acetylcholine Secretion, Neurotransmission Ion Transmembrane Transport Behavioral Response To Nicotine Regulation Of Membrane Potential Regulation Of Dendrite Morphogenesis Nervous System Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition Acetylcholine Receptor Signaling Pathway Response To Acetylcholine
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors Neutrophil degranulation	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Butabarbital Fluoxetine Dextromethorphan Ethanol Pentolinium Levacetylmethadol Epibatidine	Nicotine Butabarbital Methadone Fluoxetine Dextromethorphan Levamisole Ethanol Amantadine Pentolinium Bupropion Levacetylmethadol Gantacurium Epibatidine Cytisine
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention function in attention deficit hyperactive disorder ( 26174813) Autism spectrum disorder or schizophrenia ( 28540026) Benign childhood epilepsy with centro-temporal spikes ( 32580138) BMI (smoking interaction) ( 28443625) BMI in smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 32469254 33020668) Diffusing capacity of carbon monoxide ( 30694715) Exhaled carbon monoxide levels ( 25072098) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 18385738 18780872) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Small cell lung carcinoma ( 28604730) Smoking status (heavy vs light) ( 28520984) Squamous cell lung carcinoma ( 28604730) Sudden cardiac arrest ( 21658281)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 22080838 30804561 19300482 25101718 20173748) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Dentures ( 31235808) Diffusing capacity of carbon monoxide ( 30694715) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Exhaled carbon monoxide levels ( 25072098) Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Familial lung cancer ( 29924316) Local histogram emphysema pattern ( 25006744) Lung adenocarcinoma ( 19836008) Lung cancer ( 18385676 18385738 19654303 18780872 30104567) Lung cancer in ever smokers ( 30104567) Lung function (FEV1/FVC) ( 31453325) Lung function (FEV1/FVC) variance ( 31453325) Nicotine dependence ( 18385739 26440539) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity-related traits ( 23251661) Parental lifespan ( 30642433 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 31285632) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656 30285260) Serum albumin level ( 23022100) Smoking behavior ( 20418889 20418890) Smoking behaviour (cigarettes smoked per day) ( 31089300 30617275) Smoking status (heavy vs light) ( 28520984) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		6 interacting genes: CHRNA2 CHRNA3 CHRNA4 CHRNA5 MEOX2 UBQLN1	2 interacting genes: CHRNB4 UBQLN1
Entrez ID		1143	1136
HPRD ID		00337	07511
Ensembl ID		ENSG00000117971	ENSG00000080644
Uniprot IDs		P30926	P32297
PDB IDs		2ASG 6PV7 6PV8	4ZK4 5SYO 5TVC 6PV7 6PV8
Enriched GO Terms of Interacting Partners?
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