CHRNA2 and CHRNB4

Data Source:
HPRD (in vivo, in vitro)

		CHRNA2	CHRNB4
Description		cholinergic receptor nicotinic alpha 2 subunit	cholinergic receptor nicotinic beta 4 subunit
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Neuron Projection Synapse Postsynaptic Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Specific Granule Membrane Neuron Projection Synapse Postsynaptic Membrane Tertiary Granule Membrane
	Molecular Function	Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Protein-containing Complex Binding
	Biological Process	Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential	Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Regulation Of Membrane Potential Neutrophil Degranulation Regulation Of Neurotransmitter Secretion Nervous System Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors Neutrophil degranulation
Drugs		Nicotine Butabarbital Carbamoylcholine Metocurine iodide Fluoxetine Gallamine triethiodide Dextromethorphan Cisatracurium Mecamylamine Procaine Rocuronium Atracurium besylate Ethanol Doxacurium Tubocurarine Mivacurium Decamethonium Metocurine Pancuronium Pipecuronium Vecuronium RPI-78M Epibatidine Hexamethonium	Nicotine Butabarbital Fluoxetine Dextromethorphan Ethanol Pentolinium Levacetylmethadol Epibatidine
Diseases		Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Autism spectrum disorder or schizophrenia ( 28540026) Cannabis use disorder ( 31209380) Lung cancer ( 28604730) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia ( 29483656)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention function in attention deficit hyperactive disorder ( 26174813) Autism spectrum disorder or schizophrenia ( 28540026) Benign childhood epilepsy with centro-temporal spikes ( 32580138) BMI (smoking interaction) ( 28443625) BMI in smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 32469254 33020668) Diffusing capacity of carbon monoxide ( 30694715) Exhaled carbon monoxide levels ( 25072098) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 18385738 18780872) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Small cell lung carcinoma ( 28604730) Smoking status (heavy vs light) ( 28520984) Squamous cell lung carcinoma ( 28604730) Sudden cardiac arrest ( 21658281)
Interacting Genes		2 interacting genes: CHRNB2 CHRNB4	6 interacting genes: CHRNA2 CHRNA3 CHRNA4 CHRNA5 MEOX2 UBQLN1
Entrez ID		1135	1143
HPRD ID		00332	00337
Ensembl ID		ENSG00000120903	ENSG00000117971
Uniprot IDs		Q15822	P30926
PDB IDs		5FJV	2ASG 6PV7 6PV8
Enriched GO Terms of Interacting Partners?
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