PDAP1 and PDGFA

Data Source:
HPRD (in vitro)

		PDAP1	PDGFA
Description		PDGFA associated protein 1	platelet derived growth factor subunit A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Ficolin-1-rich Granule Lumen	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Microvillus Cell Surface Platelet Alpha Granule Lumen
	Molecular Function	RNA Binding Protein Binding	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding Growth Factor Receptor Binding
	Biological Process	Signal Transduction Neutrophil Degranulation	MAPK Cascade Angiogenesis Cell Activation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Platelet Degranulation Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Wounding Animal Organ Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Smooth Muscle Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Wound Healing Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Skin Development Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Glomerular Mesangial Cell Proliferation Embryonic Lung Development Regulation Of DNA Biosynthetic Process
Pathways		Neutrophil degranulation	Non-integrin membrane-ECM interactions
Drugs
Diseases			Malignant pleural mesothelioma Glioma
GWAS		Facial emotion recognition (sad faces) ( 28608620) Mean spheric corpuscular volume ( 32888494) Serum metabolite levels ( 23093944)	Male-pattern baldness ( 28196072)
Interacting Genes		6 interacting genes: APP CSNK2A1 FZD7 PDGFA PDGFB PDGFRB	17 interacting genes: A2M ASPH COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 DUSP3 FURIN HSPG2 MBD3 MDFI PDAP1 PDGFRA SPARC
Entrez ID		11333	5154
HPRD ID		06149	01424
Ensembl ID		ENSG00000106244	ENSG00000197461
Uniprot IDs		Q13442	P04085
PDB IDs			3MJK
Enriched GO Terms of Interacting Partners?
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