ACOT7 and UBXN1

Data Source:
BioGRID (two hybrid)

		ACOT7	UBXN1
Description		acyl-CoA thioesterase 7	UBX domain protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Extracellular Exosome	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Dendrite VCP-NPL4-UFD1 AAA ATPase Complex Neuronal Cell Body
	Molecular Function	Fatty-acyl-CoA Binding Protein Binding Palmitoyl-CoA Hydrolase Activity Long-chain Fatty Acyl-CoA Binding Protein Homodimerization Activity Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Myristoyl-CoA Hydrolase Activity	Protein Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding ATPase Binding K6-linked Polyubiquitin Modification-dependent Protein Binding Proteasome Regulatory Particle Binding
	Biological Process	Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Coenzyme A Biosynthetic Process Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process Medium-chain Fatty Acid Biosynthetic Process Palmitic Acid Biosynthetic Process	Protein Folding Viral Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-specific Protease Activity
Pathways		Mitochondrial Fatty Acid Beta-Oxidation	N-glycan trimming in the ER and Calnexin/Calreticulin cycle Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Metabolite levels ( 31628463) QT interval ( 19305408)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		24 interacting genes: ACOT12 ATXN1 ATXN1L BAG4 CAMK2B CDC42 CRYAB DAZAP2 DLC1 ENKD1 LMNA MAGEA3 MAGEA6 NCOA5 POT1 POU6F1 SPATC1L TERF1 THAP1 TINF2 UBQLN1 UBQLN2 UBXN1 ZNF438	19 interacting genes: ACOT7 ACVR1 BARD1 BMPR1B BRCA1 FAM189A2 HOMER2 PLA2G4A PLAA POLR3C RAD23A SMAD1 SMURF1 TGFBR1 TRIM39 UBC UBE2I UBQLN1 UBQLN2
Entrez ID		11332	51035
HPRD ID		12517	11266
Ensembl ID		ENSG00000097021	ENSG00000162191
Uniprot IDs		O00154	A0A024R539 A0A024R598 A0A087WTZ5 Q04323
PDB IDs		2QQ2
Enriched GO Terms of Interacting Partners?
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