CHN2 and SENP8

Data Source:
BioGRID (two hybrid)

		CHN2	SENP8
Description		chimerin 2	SUMO peptidase family member, NEDD8 specific
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GO Annotations	Cellular Component	Cytosol Membrane Synapse	Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Protein Deubiquitination Post-translational Protein Modification
Pathways		Rho GTPase cycle	UCH proteinases Neddylation
Drugs
Diseases
GWAS		Circulating leptin levels in high cardiovascular risk ( 31766143) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Facial emotion recognition ( 28608620) Facial emotion recognition (angry faces) ( 28608620) Facial emotion recognition (sad faces) ( 28608620) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Loneliness (linear analysis) ( 27629369) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Psychosis (atypical) ( 24132900) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 28552196)	Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		14 interacting genes: ANKK1 BAG6 ERBB3 NCK1 NCK2 RAC1 RACGAP1 RANBP3 RB1 SENP8 SHF SMARCD1 TGFBR1 TP53RK	15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28
Entrez ID		1124	123228
HPRD ID		04173	09784
Ensembl ID		ENSG00000106069	ENSG00000166192
Uniprot IDs		A0A2X0TVW3 B3VCF4 B3VCF5 B3VCF6 B3VCF9 B7Z1V0 B7Z1W9 B7Z215 B7Z232 P52757	A8K8D3 Q96LD8
PDB IDs		1XA6	1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?
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