AKAP10 and SASH1

Data Source:
BioGRID (two hybrid)

		AKAP10	SASH1
Description		A-kinase anchoring protein 10	SAM and SH3 domain containing 1
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GO Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Protein-containing Complex	Cytoplasm Protein-containing Complex
	Molecular Function	Protein Binding Protein Kinase A Binding	G-protein Alpha-subunit Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity
	Biological Process	Signal Transduction Blood Coagulation Protein Localization	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Autoubiquitination
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Mean platelet volume ( 27863252) Neutrophil count ( 32888494) Platelet count ( 22139419 32888494 27863252) Schizophrenia ( 28991256) Strenuous sports or other exercises ( 29899525)	Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		7 interacting genes: IKZF3 PDZK1 PRKAR1A PRKAR2A PRKAR2B SASH1 SLC9A3R1	26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN
Entrez ID		11216	23328
HPRD ID		05259	06408
Ensembl ID		ENSG00000108599	ENSG00000111961
Uniprot IDs		A0A0S2Z4Z7 E7EMD6 O43572	O94885
PDB IDs		3IM4 3TMH	2DL0 2EBP
Enriched GO Terms of Interacting Partners?
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