SASH1 and PPP4R1

Data Source:
BioGRID (two hybrid)

		SASH1	PPP4R1
Description		SAM and SH3 domain containing 1	protein phosphatase 4 regulatory subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Protein-containing Complex	Protein Serine/threonine Phosphatase Complex Protein Phosphatase 4 Complex
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Protein C-terminus Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Molecular Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Angiogenesis Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Protein Autoubiquitination	Protein Phosphorylation Protein Dephosphorylation Signal Transduction Regulation Of Phosphoprotein Phosphatase Activity
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 20061627) Chronotype ( 30696823) Gait speed in old age ( 28077804) Hypothyroidism ( 27182965) Idiopathic dilated cardiomyopathy ( 29495422) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Pneumococcal meningitis x streptococcus pneumoniae antigen allele interaction ( 31092817) Protein quantitative trait loci ( 18464913) Resting-state electroencephalogram vigilance ( 29703947) Rotator cuff tears ( 26350878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes nephropathy ( 21150874)	Lean body mass ( 28552196) Metabolite levels ( 23823483) Platelet distribution width ( 27863252)
Interacting Genes		26 interacting genes: AFF1 AKAP10 ARRB1 ASCC2 C1D CCNDBP1 CNKSR1 CRK CRKL CTNNA1 EPS8L2 EXOC8 IKBKB JADE2 JADE3 KHDRBS1 KIF3B PPP4R1 RBM12B SECISBP2L SKIL SNX1 SPG7 SYNE2 TNKS2 UTRN	5 interacting genes: CEP63 DISC1 HDAC3 PPP4C SASH1
Entrez ID		23328	9989
HPRD ID		06408	05366
Ensembl ID		ENSG00000111961	ENSG00000154845
Uniprot IDs		O94885	Q8TF05
PDB IDs		2DL0 2EBP
Enriched GO Terms of Interacting Partners?
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