AKAP10 and PRKAR1A

Data Source:
HPRD (two hybrid, in vitro)

		AKAP10	PRKAR1A
Description		A-kinase anchoring protein 10	protein kinase cAMP-dependent type I regulatory subunit alpha
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GO Annotations	Cellular Component	Mitochondrion Cytosol Plasma Membrane Protein-containing Complex	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Sperm Connecting Piece Ciliary Base Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Kinase A Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Signal Transduction Blood Coagulation Protein Localization	Mesoderm Formation Renal Water Homeostasis Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Blood Coagulation Regulation Of Protein Kinase A Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Regulation Of CAMP-mediated Signaling Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Factors involved in megakaryocyte development and platelet production	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases			Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Mean platelet volume ( 27863252) Neutrophil count ( 32888494) Platelet count ( 22139419 32888494 27863252) Schizophrenia ( 28991256) Strenuous sports or other exercises ( 29899525)	Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972)
Interacting Genes		7 interacting genes: IKZF3 PDZK1 PRKAR1A PRKAR2A PRKAR2B SASH1 SLC9A3R1	47 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP5 AKAP7 ARFGEF2 BAHD1 C11orf49 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SPART TAB1 TULP3 WDCP WNK1 YWHAZ ZBED1
Entrez ID		11216	5573
HPRD ID		05259	01786
Ensembl ID		ENSG00000108599	ENSG00000108946
Uniprot IDs		A0A0S2Z4Z7 E7EMD6 O43572	B2R5T5 P10644
PDB IDs		3IM4 3TMH	5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?
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