CHM and RAB4A

Data Source:
HPRD (two hybrid)

		CHM	RAB4A
Description		CHM Rab escort protein	RAB4A, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex	Endosome Cytosol Plasma Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Postsynaptic Recycling Endosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Rab Geranylgeranyltransferase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Syntaxin Binding Ionotropic Glutamate Receptor Binding ATPase Binding
	Biological Process	Protein Targeting To Membrane Small GTPase Mediated Signal Transduction Visual Perception Vesicle-mediated Transport Protein Phosphopantetheinylation Protein Geranylgeranylation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Post-translational Protein Modification	Phosphatidylinositol Biosynthetic Process Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Positive Regulation Of ATPase Activity
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling
Drugs
Diseases		Choroideremia (CHM); Tapetochoroidal dystrophy
GWAS		Metabolite levels ( 23823483) Pit-and-Fissure caries ( 24556642) Smooth-surface caries ( 24556642)	Aging ( 22773346) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)
Interacting Genes		11 interacting genes: RAB14 RAB18 RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5B RAB6A RAB7A	33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 FAM71C GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830
Entrez ID		1121	5867
HPRD ID		02312	01541
Ensembl ID		ENSG00000188419	ENSG00000168118
Uniprot IDs		A8K545 B4DRL9 P24386	A0A024R3U9 A0A087WYT5 P20338
PDB IDs			1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?