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MAP3K7 and MUL1
Data Source:
BioGRID
(pull down)
MAP3K7
MUL1
Description
mitogen-activated protein kinase kinase kinase 7
mitochondrial E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Nucleus
Ada2/Gcn5/Ada3 Transcription Activator Complex
Cytosol
Plasma Membrane
IkappaB Kinase Complex
Endosome Membrane
Mitochondrion
Peroxisome
Membrane
Axon
Integral Component Of Mitochondrial Outer Membrane
Neuronal Cell Body
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Receptor Tyrosine Kinase Binding
Identical Protein Binding
Scaffold Protein Binding
P53 Binding
Ubiquitin-protein Transferase Activity
Protein Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Activation Of MAPKK Activity
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
I-kappaB Phosphorylation
JNK Cascade
Viral Process
Positive Regulation Of Macroautophagy
Protein Deubiquitination
Positive Regulation Of Interleukin-2 Production
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Anoikis
Positive Regulation Of JUN Kinase Activity
Histone H3 Acetylation
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein Polyubiquitination
Mitochondrial Fission
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Activation Of JUN Kinase Activity
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Protein Ubiquitination
Protein Sumoylation
Negative Regulation Of Cell Growth
Protein Destabilization
Positive Regulation Of Protein Sumoylation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Innate Immune Response
Negative Regulation Of Defense Response To Virus By Host
Protein Stabilization
Mitochondrion Localization
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Exogenous DsRNA
Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of Mitochondrial Fission
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Dendrite Extension
Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization
Pathways
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Ub-specific processing proteases
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Asthma (
31959851
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Bone mineral density (hip) (
30172743
)
Celiac disease (
20190752
)
Graves' disease (
21841780
)
Response to anti-TNF therapy in rheumatoid arthritis (
26776603
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Proportion of activated microglia (inferior temporal cortex) (
30679421
)
Interacting Genes
67 interacting genes:
AKTIP
BBS10
BCL10
CARD11
CHUK
COPS5
CYLD
EIF2AK2
ELP1
EZH2
FOS
GPR25
HGS
HIPK2
IKBKB
IKBKG
IL17RD
IRAK1
MAP2K4
MAP2K6
MAP3K14
MAP3K3
MAP3K5
MAP4K1
MAP4K4
MAPK14
MAPK6
MAPK8
MAPK8IP1
MAVS
MUL1
NAIP
NDUFS6
NFKBIA
NOD2
NRIP1
PEBP1
PELI3
PINK1
PPM1B
PPM1L
PPP2R1A
PPP5C
PRKAB1
RBX1
RELA
RNF19A
ROR2
SMAD3
SMAD6
SMAD7
STAT3
STRADB
TAB1
TAB2
TAB3
TGFBR1
TNFRSF11A
TRAF3
TRAF3IP2
TRAF6
UBASH3A
UBC
VRK2
XIAP
ZNF593
ZNF746
34 interacting genes:
AKT1
APPBP2
CDC34
DNM1L
EHD1
HTRA2
KRTAP10-8
MAP3K7
RANGAP1
REEP2
STING1
SUMO1
TAP1
TP53
TP73
TRIM9
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2L3
UBE2L6
UBE2N
UBE2R2
UBE2U
UBE2V2
UBE2W
UBXN7
ULK1
Entrez ID
6885
79594
HPRD ID
04011
07799
Ensembl ID
ENSG00000135341
ENSG00000090432
Uniprot IDs
O43318
A1PUM0
Q969V5
PDB IDs
2EVA
2YIY
4GS6
4L3P
4L52
4L53
4O91
5E7R
5GJD
5GJF
5GJG
5J7S
5J8I
5J9L
5JGA
5JGB
5JGD
5JH6
5JK3
5V5N
6K2K
Enriched GO Terms of Interacting Partners
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