PTPRT and PTPRN

Data Source:
HPRD (two hybrid, in vitro)

		PTPRT	PTPRN
Description		protein tyrosine phosphatase receptor type T	protein tyrosine phosphatase receptor type N
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Nucleus Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Secretory Granule Transport Vesicle Membrane Neuronal Cell Body Perikaryon Axon Terminus Synapse
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Thiolester Hydrolase Activity Protein Phosphatase Binding Protein Homodimerization Activity Alpha-catenin Binding Gamma-catenin Binding Cadherin Binding Alpha-actinin Binding Delta-catenin Binding STAT Family Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding Transcription Factor Binding Spectrin Binding Ubiquitin-like Protein Ligase Binding GTPase Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Regulation Of Synapse Organization Cellular Response To Interleukin-6 Negative Regulation Of Receptor Signaling Pathway Via STAT Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity	Response To Reactive Oxygen Species Luteinization Cytokine-mediated Signaling Pathway Insulin Secretion Response To Insulin Peptidyl-tyrosine Dephosphorylation Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II Response To CAMP Positive Regulation Of Type B Pancreatic Cell Proliferation Dense Core Granule Maturation
Pathways
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Anxiety and stress-related disorders ( 31116379) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Eye morphology ( 29921221) Facial attractiveness (male raters) ( 30946739) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Household income (MTAG) ( 31844048) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Periodontitis (Mean PAL) ( 24024966) Problematic alcohol use in trauma-exposed individuals ( 29082582) Recurrence of malaria infection (mild or asymptomatic) ( 31667592) Recurrence of mild malaria attacks ( 31667592) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Systolic blood pressure ( 27841878) Temporal pole volume ( 31530798) Urate levels in obese individuals ( 25811787) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean reticulocyte volume ( 32888494)
Interacting Genes		4 interacting genes: EGFR ERBB2 ERBB4 PTPRN	19 interacting genes: CAPN2 CCDC134 CLN8 GJA8 GPR152 MADD MAL NOS1 PLP1 PPIA PTPRS PTPRT SNTB2 SNX19 SPTBN4 TIMMDC1 TMEM80 TRDN UBQLN4
Entrez ID		11122	5798
HPRD ID		06690	03466
Ensembl ID		ENSG00000196090	ENSG00000054356
Uniprot IDs		A0A075B6H0 O14522	Q16849 Q96IA0
PDB IDs		2OOQ	2I1Y 2QT7 3N01 3N4W 3NG8 3NP5
Enriched GO Terms of Interacting Partners?
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