CHD4 and CD27

Data Source:
BioGRID (affinity chromatography technology)

		CHD4	CD27
Description		chromodomain helicase DNA binding protein 4	CD27 molecule
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm Centrosome Membrane NuRD Complex Protein-containing Complex RNA Polymerase II Transcription Regulator Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding Transcription Factor Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding	Transmembrane Signaling Receptor Activity Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Regulation Of Transcription By RNA Polymerase II DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Regulation Of Signal Transduction By P53 Class Mediator	Cell Surface Receptor Signaling Pathway Immunoglobulin Mediated Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription Potential therapeutics for SARS	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Myopia (pathological) ( 23049088)	Crohn's disease ( 26192919)
Interacting Genes		21 interacting genes: ATM ATR CSNK2A1 EP300 H3-4 H3C1 HDAC1 IKZF4 MBD3L2 MTNR1A PSTPIP1 PTEN RNF8 RORC SMARCA4 SUMO2 TRIM27 TTN TWIST1 UBE2I XRN1	8 interacting genes: ACTN2 CD70 CIB1 SIVA1 TRAF2 TRAF3 TRAF5 UHRF2
Entrez ID		1108	939
HPRD ID		04472	01723
Ensembl ID		ENSG00000111642	ENSG00000139193
Uniprot IDs		F5GWX5 Q14839	P26842
PDB IDs		1MM2 1MM3 2EE1 2L5U 2L75 2N5N 4O9I 6BGG 6Q3M 6RYR 6RYU	5TL5 5TLJ 5TLK
Enriched GO Terms of Interacting Partners?
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