TPPP and DYNLL2

Data Source:
BioGRID (pull down, protein complementation assay)

		TPPP	DYNLL2
Description		tubulin polymerization promoting protein	dynein light chain LC8-type 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Microtubule Perinuclear Region Of Cytoplasm Mitotic Spindle Microtubule Bundle Postsynaptic Golgi Apparatus	Nucleus Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Postsynaptic Density Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding Microtubule Binding Tubulin Binding Protein Homodimerization Activity	Motor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding
	Biological Process	Microtubule Bundle Formation Oligodendrocyte Development Astral Microtubule Organization Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Myelination Positive Regulation Of Protein Polymerization Myelin Assembly Microtubule Polymerization Oligodendrocyte Differentiation Cell Division Microtubule Nucleation By Microtubule Organizing Center Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Tubulin Deacetylation	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Intraciliary Transport Involved In Cilium Assembly Cilium Assembly Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed
Pathways			Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Esophageal adenocarcinoma ( 27527254) Estimated glomerular filtration rate ( 31152163) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Idiopathic downbeat nystagmus ( 32157568) Ulcerative colitis ( 28067908 20228799)	Blood protein levels ( 30072576)
Interacting Genes		10 interacting genes: APP CDK11B DYNLL2 GAPDH GSK3B HDAC6 ROCK1 SNCA TUBB ZNF114	35 interacting genes: BCL2L11 BMF C12orf40 C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HMBOX1 HOMER3 IHO1 KANK2 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 SECISBP2L SKAP1 SMCP SPAG8 THAP10 TLK1 TPPP XIAP ZAR1
Entrez ID		11076	140735
HPRD ID		18522	06489
Ensembl ID		ENSG00000171368	ENSG00000264364
Uniprot IDs		O94811 Q4L233	Q96FJ2
PDB IDs			2XQQ 3P8M 4D07
Enriched GO Terms of Interacting Partners?
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