TRIM31 and USP7

Data Source:
BioGRID (two hybrid)

		TRIM31	USP7
Description		tripartite motif containing 31	ubiquitin specific peptidase 7
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body PML Body Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	P53 Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Viral Transcription Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell	Regulation Of Gluconeogenesis Transcription-coupled Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Maintenance Of DNA Methylation Viral Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of DNA Demethylation Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi
Pathways		Interferon gamma signaling	Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization
Drugs
Diseases
GWAS		Anger ( 24489884) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 28240269) Estimated glomerular filtration rate in diabetes ( 31451708) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Isovolumetric relaxation time ( 28394258) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 27863252) Neuroticism ( 29255261) Prostate cancer ( 25217961) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Type 1 diabetes and autoimmune thyroid diseases ( 25936594)	Chronotype ( 30696823) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)
Interacting Genes		22 interacting genes: CCT6A EID3 IKBKG MAGEA1 MAGEA2B MKRN3 MNAT1 NLRP3 NSMCE4A TRAF2 TRIM23 TRIM27 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2W USP7 ZSCAN1	103 interacting genes: ABRAXAS2 ACD ANKS1A ANXA1 ARNT2 ATXN1 AXIN1 BCOR BEND5 CBX8 CLSPN CREB3L3 CRY1 CSNK2A1 DAXX DCTPP1 DNAJA3 DNMT3A ERCC6 EWSR1 FOXN2 GATA1 H2AC20 H2BU1 HECW1 HERPUD1 HIF1A HTRA2 HUWE1 IFNAR1 KAT5 KDM1A KLHL8 LINC02582 MAGEE1 MAL MARCHF7 MCMBP MDM2 MDM4 MYC MYD88 NECAB2 NOTCH1 OTUD4 PCGF2 PEG3 PEPD PHF8 PHLDB2 PICK1 PLA2G2A PLEKHO1 PLK1 PPARG PPL PSMD4 PTEN RAD18 RADIL RARA RB1 RBCK1 RELA RFFL RNF168 RNF220 SIRT7 SMAD3 SNCA SUMO2 SYVN1 TANK TBCB TFIP11 TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBA52 UBC UBE2D3 UBE2E1 UBE2S USP21 USP28 VCP WWP2 XPC ZMYND8 ZNF423 ZNF76
Entrez ID		11074	7874
HPRD ID		10281	03950
Ensembl ID		ENSG00000204616	ENSG00000187555
Uniprot IDs		Q2L6J1 Q9BZY9	B7Z855 B7ZAX6 Q6U8A4 Q93009
PDB IDs		2YSJ 2YSL	1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2
Enriched GO Terms of Interacting Partners?
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