WWP1 and DIDO1

Data Source:
BioGRID (two hybrid)

		WWP1	DIDO1
Description		WW domain containing E3 ubiquitin protein ligase 1	death inducer-obliterator 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Nucleus Cytoplasm Spindle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	RNA Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	Transcription, DNA-templated Apoptotic Signaling Pathway
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Mean corpuscular volume ( 32888494) Menopause (age at onset) ( 26414677)
Interacting Genes		55 interacting genes: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	12 interacting genes: APP ARAF DVL3 H3-4 HNRNPK KCNK4 LRRK2 SRPK2 SRSF1 SUMO2 WWP1 WWP2
Entrez ID		11059	11083
HPRD ID		03811	10363
Ensembl ID		ENSG00000123124	ENSG00000101191
Uniprot IDs		Q9H0M0	Q9BTC0
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y	2M3H 4L7X
Enriched GO Terms of Interacting Partners?
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