WWP1 and IL6R

Data Source:
HPRD (in vitro)

		WWP1	IL6R
Description		WW domain containing E3 ubiquitin protein ligase 1	interleukin 6 receptor
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Extracellular Region Plasma Membrane Interleukin-6 Receptor Complex External Side Of Plasma Membrane Apical Plasma Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding
	Biological Process	Protein Polyubiquitination Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	Hepatic Immune Response Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Response To Cytokine Interleukin-11-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Glomerular Mesangial Cell Proliferation T-helper 17 Cell Lineage Commitment Extrinsic Apoptotic Signaling Pathway
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling Transcriptional regulation of granulopoiesis Potential therapeutics for SARS
Drugs			Tocilizumab Sarilumab Satralizumab
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Abdominal aortic aneurysm ( 27899403) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187) Asthma ( 32296059 21907864) Atopic dermatitis ( 26482879) Atrial fibrillation ( 29892015) Blood protein levels ( 30072576 29875488 28240269 23696881) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein ( 19567438 18439548) C-reactive protein levels ( 29403010 30388399 21300955) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Fibrinogen ( 20031577 23969696) Fibrinogen levels ( 28107422 26561523) Interleukin-6 levels ( 32473944) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Platelet count ( 32888494) Protein quantitative trait loci ( 18464913) Pulmonary function ( 17903307) Red cell distribution width ( 32888494) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469)
Interacting Genes		55 interacting genes: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	11 interacting genes: ADRB2 CNTF ERAP1 IL6 IL6ST MAGI1 SGTB SRC STAT3 WWP1 WWP2
Entrez ID		11059	3570
HPRD ID		03811	01000
Ensembl ID		ENSG00000123124	ENSG00000160712
Uniprot IDs		Q9H0M0	A0A087WTB5 A0N0L5 P08887
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y	1N26 1N2Q 1P9M 2ARW 5FUC
Enriched GO Terms of Interacting Partners?
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