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CLP1 and PSMB5
Data Source:
BioGRID
(two hybrid)
CLP1
PSMB5
Description
cleavage factor polyribonucleotide kinase subunit 1
proteasome 20S subunit beta 5
Image
No pdb structure
GO Annotations
Cellular Component
TRNA-intron Endonuclease Complex
Nucleus
Nucleoplasm
Cytosol
MRNA Cleavage Factor Complex
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Extracellular Exosome
Molecular Function
Protein Binding
ATP Binding
ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
Polynucleotide 5'-hydroxyl-kinase Activity
Polydeoxyribonucleotide Kinase Activity
ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Biological Process
MRNA Splicing, Via Spliceosome
Termination Of RNA Polymerase II Transcription
MRNA Polyadenylation
TRNA Splicing, Via Endonucleolytic Cleavage And Ligation
RNA Processing
Phosphorylation
Cerebellar Cortex Development
Targeting Of MRNA For Destruction Involved In RNA Interference
MRNA 3'-end Processing
SiRNA Loading Onto RISC Involved In RNA Interference
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Proteolysis
Regulation Of Cellular Amino Acid Metabolic Process
Response To Oxidative Stress
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
tRNA processing in the nucleus
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Processing of Intronless Pre-mRNAs
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Bortezomib
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Carfilzomib
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Neuroticism (
29255261
)
Schizophrenia (
25056061
29483656
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
32888494
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Interacting Genes
17 interacting genes:
APP
CCDC130
CEP164
CPSF3
CREB3
DAGLB
FGF16
FTO
HCFC1
MEOX2
MESD
NUDT21
PCMT1
PRR3
PSMB5
SNF8
TSEN54
28 interacting genes:
ABCB5
BAG4
CCDC150
CLP1
DUSP29
GAGE12G
GAGE2E
IKBKG
LSM1
NTAQ1
PIK3R1
PLK1
POMP
PRNP
PSMA1
PSMA2
PSMA3
PSMA6
PSMB1
PSMB3
PSMB4
PSMB7
PSMG3
TAP1
TAP2
TCHP
TRAF6
XRN1
Entrez ID
10978
5693
HPRD ID
16382
02629
Ensembl ID
ENSG00000172409
ENSG00000100804
Uniprot IDs
Q92989
A0A140VJS7
P28074
PDB IDs
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5L5W
5L5X
5L5Y
5L5Z
5L60
5L61
5L62
5L63
5L64
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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