CLP1 and CEP164

Data Source:
BioGRID (two hybrid)

		CLP1	CEP164
Description		cleavage factor polyribonucleotide kinase subunit 1	centrosomal protein 164
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleus Nucleoplasm Cytosol MRNA Cleavage Factor Complex	Extracellular Space Nucleoplasm Centrosome Centriole Cytosol Ciliary Transition Fiber
	Molecular Function	Protein Binding ATP Binding ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity Polydeoxyribonucleotide Kinase Activity ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation TRNA Splicing, Via Endonucleolytic Cleavage And Ligation RNA Processing Phosphorylation Cerebellar Cortex Development Targeting Of MRNA For Destruction Involved In RNA Interference MRNA 3'-end Processing SiRNA Loading Onto RISC Involved In RNA Interference	G2/M Transition Of Mitotic Cell Cycle DNA Repair Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Division Cilium Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways		tRNA processing in the nucleus mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Neuroticism ( 29255261) Schizophrenia ( 25056061 29483656)	Apolipoprotein A1 levels ( 32203549) Diastolic blood pressure ( 30578418) Diffusing capacity of carbon monoxide ( 30694715) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Pulse pressure ( 28135244 27841878 30578418)
Interacting Genes		17 interacting genes: APP CCDC130 CEP164 CPSF3 CREB3 DAGLB FGF16 FTO HCFC1 MEOX2 MESD NUDT21 PCMT1 PRR3 PSMB5 SNF8 TSEN54	5 interacting genes: ATR ATRIP CLP1 MAPK14 UBC
Entrez ID		10978	22897
HPRD ID		16382	10854
Ensembl ID		ENSG00000172409	ENSG00000110274
Uniprot IDs		Q92989	Q9UPV0
PDB IDs
Enriched GO Terms of Interacting Partners?
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