BTG3 and CNOT7

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		BTG3	CNOT7
Description		BTG anti-proliferation factor 3	CCR4-NOT transcription complex subunit 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	Protein Binding	3'-5'-exoribonuclease Activity Transcription Corepressor Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle	Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Translation Gene Silencing By RNA P-body Assembly Gene Silencing By MiRNA Regulation Of Tyrosine Phosphorylation Of STAT Protein Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways			Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Corpus callosum central volume ( 31530798) Feeling hurt ( 29500382)
Interacting Genes		4 interacting genes: ATXN1 BANP CACNA1A CNOT7	28 interacting genes: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI PABPC1 PIAS1 PSMC1 PSMC2 SCARA3 SH3GLB2 TCP11L1 TEX11 TOB1 TOB2 TSG101
Entrez ID		10950	29883
HPRD ID		10415	05370
Ensembl ID		ENSG00000154640	ENSG00000198791
Uniprot IDs		Q14201 Q6IAU3	Q96IQ6 Q9UIV1
PDB IDs			2D5R 4GMJ
Enriched GO Terms of Interacting Partners?
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