DBF4 and MCM6

Data Source:
BioGRID (enzymatic study)

		DBF4	MCM6
Description		DBF4 zinc finger	minichromosome maintenance complex component 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex CMG Complex
	Molecular Function	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Body mass index ( 25673413) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		18 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6	38 interacting genes: C2CD6 CCNA1 CDC42 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 TRIM28 UBE3A ZBTB9
Entrez ID		10926	4175
HPRD ID		10371	03485
Ensembl ID		ENSG00000006634	ENSG00000076003
Uniprot IDs		B4DXK0 B7Z8C6 Q9UBU7	Q14566
PDB IDs		4F99 4F9A 4F9B 4F9C 6YA6 6YA7 6YA8	2KLQ 2LE8 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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