DBF4 and ORC6

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		DBF4	ORC6
Description		DBF4 zinc finger	origin recognition complex subunit 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex	Origin Recognition Complex Fibrillar Center Nucleoplasm Nuclear Origin Of Replication Recognition Complex Membrane
	Molecular Function	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity	DNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Negative Regulation Of Cell Division
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6	19 interacting genes: APP CDC45 CDC6 CDC7 DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2
Entrez ID		10926	23594
HPRD ID		10371	06237
Ensembl ID		ENSG00000006634	ENSG00000091651
Uniprot IDs		B4DXK0 B7Z8C6 Q9UBU7	A0A024R6R3 Q9Y5N6
PDB IDs		4F99 4F9A 4F9B 4F9C 6YA6 6YA7 6YA8	3M03 6KVG
Enriched GO Terms of Interacting Partners?
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