XRN2 and ALDH1B1

Data Source:
BioGRID (two hybrid)

		XRN2	ALDH1B1
Description		5'-3' exoribonuclease 2	aldehyde dehydrogenase 1 family member B1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Aggresome	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding	Aldehyde Dehydrogenase (NAD+) Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity NAD Binding
	Biological Process	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Carbohydrate Metabolic Process Ethanol Catabolic Process Ethanol Oxidation
Pathways		Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol	Ethanol oxidation
Drugs			NADH
Diseases
GWAS		Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2	3 interacting genes: EXOSC10 FABP2 XRN2
Entrez ID		22803	219
HPRD ID		10309	00005
Ensembl ID		ENSG00000088930	ENSG00000137124
Uniprot IDs		B4DZC3 Q9H0D6	A0A384MTJ7 P30837
PDB IDs
Enriched GO Terms of Interacting Partners?
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