SLC12A7 and TMEM147

Data Source:
BioGRID (two hybrid)

		SLC12A7	TMEM147
Description		solute carrier family 12 member 7	transmembrane protein 147
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Synapse	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Ammonium Transmembrane Transporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding	Protein Binding
	Biological Process	Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Ammonium Import Across Plasma Membrane Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Cation-coupled Chloride cotransporters
Drugs		Potassium chloride
Diseases
GWAS		Granulocyte count ( 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) JT interval ( 29874175) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010 32888494 20139978 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Pancreatic cancer ( 25086665) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) PR interval ( 32439900) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		14 interacting genes: GJB1 GPR61 MS4A13 OPRD1 OTP SERINC2 SLC10A1 SLC10A6 SLC35C2 TMBIM6 TMEM147 TMEM237 TMEM54 YIPF6	54 interacting genes: ABHD16A ABI3 CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 DPM3 EBP EFNA4 ENPP4 F11R FFAR2 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PACC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC22A1 SLC22A2 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12
Entrez ID		10723	10430
HPRD ID		09221	17633
Ensembl ID		ENSG00000113504	ENSG00000105677
Uniprot IDs		Q9Y666	Q9BVK8
PDB IDs			6W6L
Enriched GO Terms of Interacting Partners?
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