CETP and ARPC3

Data Source:
HPRD (two hybrid)

		CETP	ARPC3
Description		cholesteryl ester transfer protein	actin related protein 2/3 complex subunit 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle High-density Lipoprotein Particle Extracellular Exosome	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filamentous Actin Site Of Double-strand Break Growth Cone Leading Edge Extracellular Exosome
	Molecular Function	Phospholipid Transporter Activity Lipid Binding Cholesterol Binding Triglyceride Binding Phosphatidylcholine Binding Cholesterol Transfer Activity	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Triglyceride Metabolic Process Lipid Transport Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Efflux Phospholipid Transport Cholesterol Transport Positive Regulation Of Cholesterol Transport Triglyceride Transport Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis Reverse Cholesterol Transport Phosphatidylcholine Metabolic Process Lipid Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis Intermembrane Lipid Transfer Positive Regulation Of Phospholipid Transport	Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Cellular Response To Nerve Growth Factor Stimulus
Pathways		LDL remodeling HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Torcetrapib	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636 21665990) Apolipoprotein A1 levels ( 32203549 17463246) Apolipoprotein B levels ( 32203549) Biochemical measures ( 19260141) Blood metabolite levels ( 24816252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cardiovascular risk factors ( 20838585) Cholesterol ( 20066028) Cholesterol efflux capacity ( 30369316) Cholesterol efflux capacity (cAMP stimulated assay) ( 30369316) Cholesterol, total ( 24097068 24886709 20686565 26582766) Cholesteryl ester transfer protein levels ( 29728394) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diisocyanate-induced asthma ( 25918132) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) HDL cholesterol ( 23726366 24097068 20031538 29404214 19359809 20031564 21909109 28270201 24507774 18193043 18193044 20864672 26160806 19060906 23505323 19060910 19060911 24886709 21347282 25961943 26780889 20686565 26582766) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol change in response to niacin in statin-treated individuals ( 30371334) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 32203549 31694877 28334899 26690388 26763881 17463246 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 30263045 30718733 31211820 31647587 30911093 29403010 31217584 28548082 30108155) Hypo-HDL-cholesterolemia ( 31087446) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219 19936222) Lipid or lipoprotein levels ( 23696881) Lipid traits ( 30576415 24386095 24023260 24023261) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302) Low HDL-cholesterol levels ( 31910446) Low high density lipoprotein cholesterol levels ( 26879886) Metabolic syndrome ( 22399527 21386085 20694148 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Response to fenofibrate (HDL cholesterol levels) ( 30263045) Response to statins (HDL cholesterol change) ( 27587472) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 30718733 28334899 29403010) Triglyceride levels ( 32203549 28334899 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943 20686565) Waist circumference and related phenotypes ( 18454146)	Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		6 interacting genes: APOA1 ARPC3 EWSR1 LPL PRKACG TP53	30 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576
Entrez ID		1071	10094
HPRD ID		00325	09175
Ensembl ID		ENSG00000087237	ENSG00000111229
Uniprot IDs		A0A0S2Z3F6 A0A0S2Z3I8 B4DMZ5 P11597	O15145
PDB IDs		2OBD 4EWS 4F2A	6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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