CETP and LPL

Data Source:
HPRD (in vivo)

		CETP	LPL
Description		cholesteryl ester transfer protein	lipoprotein lipase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Vesicle High-density Lipoprotein Particle Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Very-low-density Lipoprotein Particle Chylomicron
	Molecular Function	Phospholipid Transporter Activity Lipid Binding Cholesterol Binding Triglyceride Binding Phosphatidylcholine Binding Cholesterol Transfer Activity	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Heparin Binding Phospholipase A1 Activity Lipase Activity Triglyceride Binding Apolipoprotein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein-membrane Adaptor Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Lipoprotein Particle Binding
	Biological Process	Triglyceride Metabolic Process Lipid Transport Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Efflux Phospholipid Transport Cholesterol Transport Positive Regulation Of Cholesterol Transport Triglyceride Transport Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Cholesterol Homeostasis Reverse Cholesterol Transport Phosphatidylcholine Metabolic Process Lipid Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis Intermembrane Lipid Transfer Positive Regulation Of Phospholipid Transport	Retinoid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Response To Cold Response To Bacterium Response To Glucose Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Positive Regulation Of Sequestering Of Triglyceride Lipid Catabolic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Cellular Response To Nutrient Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Response To Drug Cholesterol Homeostasis Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Inflammatory Response Regulation Of Lipoprotein Lipase Activity Low-density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cellular Response To Fatty Acid Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		LDL remodeling HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport
Drugs		Torcetrapib	Tyloxapol Omega-3-carboxylic acids Glycyrrhizic acid
Diseases			Hyperlipoproteinemia, type I
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636 21665990) Apolipoprotein A1 levels ( 32203549 17463246) Apolipoprotein B levels ( 32203549) Biochemical measures ( 19260141) Blood metabolite levels ( 24816252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cardiovascular risk factors ( 20838585) Cholesterol ( 20066028) Cholesterol efflux capacity ( 30369316) Cholesterol efflux capacity (cAMP stimulated assay) ( 30369316) Cholesterol, total ( 24097068 24886709 20686565 26582766) Cholesteryl ester transfer protein levels ( 29728394) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diisocyanate-induced asthma ( 25918132) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) HDL cholesterol ( 23726366 24097068 20031538 29404214 19359809 20031564 21909109 28270201 24507774 18193043 18193044 20864672 26160806 19060906 23505323 19060910 19060911 24886709 21347282 25961943 26780889 20686565 26582766) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol change in response to niacin in statin-treated individuals ( 30371334) HDL Cholesterol in HIV-infection ( 25884002) HDL cholesterol levels ( 32203549 31694877 28334899 26690388 26763881 17463246 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 30263045 30718733 31211820 31647587 30911093 29403010 31217584 28548082 30108155) Hypo-HDL-cholesterolemia ( 31087446) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219 19936222) Lipid or lipoprotein levels ( 23696881) Lipid traits ( 30576415 24386095 24023260 24023261) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302) Low HDL-cholesterol levels ( 31910446) Low high density lipoprotein cholesterol levels ( 26879886) Metabolic syndrome ( 22399527 21386085 20694148 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Response to fenofibrate (HDL cholesterol levels) ( 30263045) Response to statins (HDL cholesterol change) ( 27587472) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 30718733 28334899 29403010) Triglyceride levels ( 32203549 28334899 29403010) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943 20686565) Waist circumference and related phenotypes ( 18454146)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Body mass index (adult) ( 28430825) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cholesterol ( 31902109) Cholesterol efflux capacity ( 30369316) Coronary artery disease ( 32469254 29212778 24262325 30104761 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil counts ( 32888494) Fasting triglyceride levels ( 32603185) Gut microbiota (beta diversity) ( 27723756) HDL cholesterol ( 23726366 24097068 20031538 21909109 28270201 24507774 18193043 18193044 20864672 26160806 19060906 19060911 21347282 25961943 26780889 20686565 26582766) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 32203549 31694877 28334899 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 30718733 30911093 29403010 29615537 28548082) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219 19936222) Lipid traits ( 24386095 24023261) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Low density lipoprotein cholesterol levels ( 32154731) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 21386085 20694148 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Peripheral artery disease ( 31285632) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Pulse pressure ( 27841878) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Susceptibility to persistent hepatitis B virus infection ( 27244555) Systolic blood pressure ( 27841878) Total triglycerides levels ( 29084231 26690388) Triacylglyceride levels ( 31551469) Triglyceride levels ( 30718733 32203549 28334899 26763881 32154731 30911093 29403010 29615537 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in small VLDL ( 29084231) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglyceride to HDL cholesterol ratio ( 28046027) Triglycerides ( 23726366 24097068 21909109 24507774 18193043 18193044 18193046 20864672 26160806 19060906 19060911 24886709 22171074 20139978 17463246 25961943 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Type 2 diabetes ( 30054458 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference and related phenotypes ( 18454146)
Interacting Genes		6 interacting genes: APOA1 ARPC3 EWSR1 LPL PRKACG TP53	17 interacting genes: APOC2 APP ASCC2 CALR CCND1 CEP126 CETP COPS6 EMD LRP1 LRP2 LUC7L2 PTPN4 RPL18A TSC22D2 UBE2Z VLDLR
Entrez ID		1071	4023
HPRD ID		00325	01999
Ensembl ID		ENSG00000087237	ENSG00000175445
Uniprot IDs		A0A0S2Z3F6 A0A0S2Z3I8 B4DMZ5 P11597	A0A1B1RVA9 P06858
PDB IDs		2OBD 4EWS 4F2A	6E7K 6OAU 6OAZ 6OB0 6WN4
Enriched GO Terms of Interacting Partners?
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