CSPG5 and CTSA

Data Source:
BioGRID (two hybrid)

		CSPG5	CTSA
Description		chondroitin sulfate proteoglycan 5	cathepsin A
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Lumen Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Golgi-associated Vesicle Membrane Lysosomal Lumen Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane	Extracellular Region Lysosome Endoplasmic Reticulum Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Lumenal Side Of Lysosomal Membrane
	Molecular Function	Protein Binding Growth Factor Activity	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity
	Biological Process	Cytoskeleton Organization Signal Transduction Nervous System Development Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Regulation Of Growth Intracellular Transport Cell Projection Morphogenesis Trans-synaptic Signaling, Modulating Synaptic Transmission Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Synaptic Vesicle Exocytosis	Proteolysis Glycosphingolipid Metabolic Process Intracellular Protein Transport Regulation Of Protein Stability Neutrophil Degranulation Regulation Of Catalytic Activity Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Chaperone-mediated Autophagy
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Glycosphingolipid metabolism MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs
Diseases			Galactosialidosis
GWAS		Body mass index ( 29273807)
Interacting Genes		3 interacting genes: CTSA ERBB3 GOPC	45 interacting genes: AHNAK2 AQP2 AQP6 ARL13B ASPH BSND CD79A COQ9 CPLX4 CREB3L1 CSPG5 ERGIC3 FAM209A FKBP7 FNDC9 GLB1 GORAB HIBADH LAMP2 LMNA LTB4R2 MFSD14B MGST3 MUC1 MYG1 NEU1 PSCA REEP4 RHBDD1 RNF122 SAR1A SGMS2 SIGLEC12 SLC18A1 SLC30A2 SPN SSMEM1 STX2 THAP4 TMEM139 TMEM154 TMEM237 TMEM31 TMEM35A TMX2
Entrez ID		10675	5476
HPRD ID		08423	02020
Ensembl ID		ENSG00000114646	ENSG00000064601
Uniprot IDs		A0A087WUT8 B7Z2E0 O95196	B4E324 P10619 X6R5C5 X6R8A1
PDB IDs			1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3 4CI9 4CIA 4CIB 4MWS 4MWT 6WIA
Enriched GO Terms of Interacting Partners?
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