CSPG5 and GOPC

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		CSPG5	GOPC
Description		chondroitin sulfate proteoglycan 5	golgi associated PDZ and coiled-coil motif containing
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Lumen Integral Component Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Golgi-associated Vesicle Membrane Lysosomal Lumen Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Trans-Golgi Network Transport Vesicle Dendrite Golgi-associated Vesicle Membrane Protein-containing Complex
	Molecular Function	Protein Binding Growth Factor Activity	Protein Binding Identical Protein Binding Ion Channel Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Nervous System Development Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Regulation Of Growth Intracellular Transport Cell Projection Morphogenesis Trans-synaptic Signaling, Modulating Synaptic Transmission Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Synaptic Vesicle Exocytosis	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Negative Regulation Of Anion Channel Activity Protein Transport Cytoplasmic Sequestering Of CFTR Protein Apical Protein Localization Negative Regulation Of Protein Localization To Cell Surface
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	RHO GTPases regulate CFTR trafficking
Drugs
Diseases
GWAS		Body mass index ( 29273807)	Atrial fibrillation ( 29892015) Colorectal cancer ( 23266556) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial emotion recognition (fearful faces) ( 28608620) Night sleep phenotypes ( 27126917)
Interacting Genes		3 interacting genes: CTSA ERBB3 GOPC	70 interacting genes: ABCA1 ADRB1 AKIRIN1 ASIC3 ATG9A BATF BECN1 C17orf67 CCDC102B CCDC198 CD300C CDKN2C CERCAM CFTR CLCN3 CRHR1 CSPG5 DLEU1 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GEM GOLGA3 GRID1 GRID2 HCK HNRNPLL IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MYLK MYOCD NOTCH1 NUP62 OSBP2 PARK7 PID1 PPP1R18 PWWP3A RALGAPB RELA RHOQ RNF183 RNF220 RPL13AP17 RPS6KA1 RTKN SEMA4G SLC25A18 SNX31 SPATA8 SSTR5 STARD3 STX6 TGFBR2 VIM VTN ZBTB49 ZDHHC1 ZNF564 ZNF581 ZNF587 ZNF835 ZSCAN1
Entrez ID		10675	57120
HPRD ID		08423	06024
Ensembl ID		ENSG00000114646	ENSG00000047932
Uniprot IDs		A0A087WUT8 B7Z2E0 O95196	Q9HD26
PDB IDs			2DC2 2LOB 4E34 4E35 4JOE 4JOF 4JOG 4JOH 4JOJ 4JOK 4JOP 4JOR 4K6Y 4K72 4K75 4K76 4K78 4NMO 4NMP 4NMQ 4NMR 4NMS 4NMT 4NMV 4Q6H 4Q6S 5IC3 5K4F 6OV7 6XNJ
Enriched GO Terms of Interacting Partners?
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