MXD4 and MLX

Data Source:
HPRD (in vivo, in vitro)

		MXD4	MLX
Description		MAX dimerization protein 4	MAX dimerization protein MLX
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Protein Dimerization Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nuclear signaling by ERBB4	ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549)	Crohn's disease ( 21102463) Type 2 diabetes ( 30297969 29632382 30718926) Type 2 diabetes (time to event) ( 32589924)
Interacting Genes		6 interacting genes: MAX MLX SHBG SIN3A SMC3 TCP10L	31 interacting genes: APP BACH2 BEND7 CASK CCT6A DDIT4L GABARAPL1 GABARAPL2 ID3 KRTAP13-3 LNX1 LNX2 MAD1L1 MEI4 MEOX1 MEOX2 MLXIP MLXIPL MNT MXD1 MXD4 PIAS2 RBM39 RHBDD2 SAP30BP TEPSIN TLE5 TNNT2 UBE2I ZBTB32 ZNF620
Entrez ID		10608	6945
HPRD ID		10103	04278
Ensembl ID		ENSG00000123933	ENSG00000108788
Uniprot IDs		Q14582	Q9UH92
PDB IDs
Enriched GO Terms of Interacting Partners?
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