SLU7 and THAP1

Data Source:
BioGRID (two hybrid)

		SLU7	THAP1
Description		SLU7 homolog, splicing factor	THAP domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Membrane Nuclear Speck Small Nuclear Ribonucleoprotein Complex Intracellular Membrane-bounded Organelle Catalytic Step 2 Spliceosome	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	Second Spliceosomal Transesterification Activity Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus Intracellular Protein Transport RNA Splicing MRNA 3'-end Processing Cellular Response To Heat	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell Cycle Regulation Of Mitotic Cell Cycle
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Asthma ( 32296059) Common carotid intima-media thickness ( 29206233)	Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		27 interacting genes: AIMP2 BAG2 CCDC85B CEP70 DEF6 FHL3 GOLGA2 GTF2I IKBKG JMJD6 KDM1A KRT40 LMNA LONRF1 LZTS2 MCC NFKBID NSD3 PCBP2 PIBF1 PPIG PPIL3 PRMT5 PRMT6 TEPSIN THAP1 ZCCHC10	105 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 C4orf45 C7orf50 CDC37 CDKN2D CHD2 CSNK2A1 DCAF8 DVL2 EEF1AKNMT FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GAS8 GPATCH2L HNRNPLL HYPK INO80B KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PHF1 PHF19 PID1 PNKP POLR2L POLR2M POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZNF385C ZNF408 ZNF526
Entrez ID		10569	55145
HPRD ID		12074	15496
Ensembl ID		ENSG00000164609	ENSG00000131931
Uniprot IDs		O95391	Q9NVV9
PDB IDs		5XJC 6ICZ 6QDV	2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?
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