GLRX3 and ZNF23

Data Source:
BioGRID (two hybrid)

		GLRX3	ZNF23
Description		glutaredoxin 3	zinc finger protein 23
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cell Cortex Z Disc Dendrite	Nucleus
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Protein Disulfide Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Cellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy [2Fe-2S] Cluster Assembly Protein Maturation By Iron-sulfur Cluster Transfer	Regulation Of Transcription By RNA Polymerase II
Pathways		Iron uptake and transport	Generic Transcription Pathway
Drugs
Diseases
GWAS		Alcohol dependence ( 26365420) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Mean corpuscular volume ( 32888494) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)	General risk tolerance (MTAG) ( 30643258) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		99 interacting genes: ADAMTSL3 ADAMTSL4 ALKBH3 BCL6 BOLA1 BOLA2 BOLA2B BOLA3 CA9 CBLB CCHCR1 CERCAM CGGBP1 CIAPIN1 COL8A1 EFEMP2 ERBB2 FAM118A FRA10AC1 GATA1 GMCL1 GNG13 GRN HEXD HSD3B7 IHO1 IKZF1 IL10 IRX6 KLHDC9 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2D LNX1 LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI METAP1 MOXD1 NADK NOTCH2NLA NTF4 OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ PRKD2 RCOR3 RECK RGS20 SMARCC1 SOX7 STAU1 STRA6 TCF4 TCL1B TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF124 ZNF148 ZNF23 ZNF426 ZNF490 ZNF512B ZNF544 ZNF774	22 interacting genes: APP ATPAF2 DYSF ELOA2 FHL2 FHL5 GLRX3 GMCL1 KRTAP10-3 KRTAP10-8 MCRS1 MDFI MEOX2 MOBP MTUS2 NME7 PCBD1 SPRY1 TRAF1 TSGA10 ZBTB9 ZNF330
Entrez ID		10539	7571
HPRD ID		10153	01915
Ensembl ID		ENSG00000108010	ENSG00000167377
Uniprot IDs		A0A140VJK1 O76003	B3KR55 B4DLS2 P17027
PDB IDs		2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?
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