GLRX3 and STRA6

Data Source:
BioGRID (two hybrid)

		GLRX3	STRA6
Description		glutaredoxin 3	signaling receptor and transporter of retinol STRA6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cell Cortex Z Disc Dendrite	Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Protein Disulfide Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding	Retinal Binding Retinol Binding Retinol Transmembrane Transporter Activity Signaling Receptor Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Cellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy [2Fe-2S] Cluster Assembly Protein Maturation By Iron-sulfur Cluster Transfer	Retinoid Metabolic Process Blood Vessel Development Kidney Development Pulmonary Valve Morphogenesis Ventricular Septum Development Heart Development Learning Feeding Behavior Lung Development Adrenal Gland Development Female Genitalia Development Retinol Transport Vocal Learning Camera-type Eye Development Ear Development Nose Morphogenesis Lung Alveolus Development Positive Regulation Of Behavior Digestive Tract Morphogenesis Embryonic Digestive Tract Development Developmental Growth Smooth Muscle Tissue Development Artery Morphogenesis Cognition Neuromuscular Process Head Development Head Morphogenesis Face Morphogenesis Lung Vasculature Development Diaphragm Development Embryonic Camera-type Eye Formation Eyelid Development In Camera-type Eye Uterus Morphogenesis Alveolar Primary Septum Development Pulmonary Artery Morphogenesis Paramesonephric Duct Development Vitamin A Import Ductus Arteriosus Closure
Pathways		Iron uptake and transport	Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision)
Drugs
Diseases			Anophthalmia and microphthalmia (A/M)
GWAS		Alcohol dependence ( 26365420) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Mean corpuscular volume ( 32888494) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)	Coffee consumption (cups per day) ( 31837886) Estimated glomerular filtration rate ( 31152163) Inhibitory control ( 29251981) Optic disc size ( 31809533)
Interacting Genes		99 interacting genes: ADAMTSL3 ADAMTSL4 ALKBH3 BCL6 BOLA1 BOLA2 BOLA2B BOLA3 CA9 CBLB CCHCR1 CERCAM CGGBP1 CIAPIN1 COL8A1 EFEMP2 ERBB2 FAM118A FRA10AC1 GATA1 GMCL1 GNG13 GRN HEXD HSD3B7 IHO1 IKZF1 IL10 IRX6 KLHDC9 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2D LNX1 LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI METAP1 MOXD1 NADK NOTCH2NLA NTF4 OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ PRKD2 RCOR3 RECK RGS20 SMARCC1 SOX7 STAU1 STRA6 TCF4 TCL1B TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF124 ZNF148 ZNF23 ZNF426 ZNF490 ZNF512B ZNF544 ZNF774	4 interacting genes: GLRX3 KRTAP10-6 KRTAP6-3 NDUFB7
Entrez ID		10539	64220
HPRD ID		10153	18122
Ensembl ID		ENSG00000108010	ENSG00000137868
Uniprot IDs		A0A140VJK1 O76003	B3KPB8 Q9BX79
PDB IDs		2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?
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