SEMA4B and PLXNB1

Data Source:
HPRD (in vitro, in vivo)

		SEMA4B	PLXNB1
Description		semaphorin 4B	plexin B1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Synapse	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Semaphorin Receptor Binding Chemorepellent Activity	Transmembrane Signaling Receptor Activity GTPase Activator Activity Protein Binding Semaphorin Receptor Activity Semaphorin Receptor Binding GTPase Activating Protein Binding Signaling Receptor Activity
	Biological Process	Neural Crest Cell Migration Axon Guidance Positive Regulation Of Cell Migration Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Semaphorin-plexin Signaling Pathway	Negative Regulation Of Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Regulation Of Cell Migration Negative Regulation Of Osteoblast Proliferation Intracellular Signal Transduction Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Inhibitory Synapse Assembly
Pathways			G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Acne (severe) ( 30542056) Frontal fibrosing alopecia ( 30850646) Pulse pressure ( 27841878)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: CPEB2 DLG4 GIPC1 PLXNB1	14 interacting genes: ARHGEF11 ARHGEF12 KMT2A L1CAM MET NRP1 NRP2 PLXNA1 RAC1 RND1 RND3 SEMA4B SEMA4D SOX4
Entrez ID		10509	5364
HPRD ID		10217	03032
Ensembl ID		ENSG00000185033	ENSG00000164050
Uniprot IDs		Q9NPR2	O43157
PDB IDs			2JPH 2OS6 2R2O 2REX 3HM6 3OL2 3SU8 3SUA 5B4W
Enriched GO Terms of Interacting Partners?
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