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PLXNB1 and NRP2
Data Source:
BioGRID
(two hybrid)
PLXNB1
NRP2
Description
plexin B1
neuropilin 2
Image
GO Annotations
Cellular Component
Semaphorin Receptor Complex
Extracellular Region
Plasma Membrane
Integral Component Of Plasma Membrane
Semaphorin Receptor Complex
Extracellular Region
Plasma Membrane
Membrane
Integral Component Of Membrane
Axon
Glutamatergic Synapse
Integral Component Of Postsynaptic Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
GTPase Activator Activity
Protein Binding
Semaphorin Receptor Activity
Semaphorin Receptor Binding
GTPase Activating Protein Binding
Signaling Receptor Activity
Vascular Endothelial Growth Factor-activated Receptor Activity
Protein Binding
Heparin Binding
Semaphorin Receptor Activity
Growth Factor Binding
Cytokine Binding
Signaling Receptor Activity
Metal Ion Binding
Biological Process
Negative Regulation Of Cell Adhesion
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Regulation Of Cell Shape
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cell Migration
Regulation Of Cell Migration
Negative Regulation Of Osteoblast Proliferation
Intracellular Signal Transduction
Regulation Of GTPase Activity
Positive Regulation Of GTPase Activity
Ossification Involved In Bone Maturation
Neuron Projection Morphogenesis
Positive Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Semaphorin-plexin Signaling Pathway
Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis
Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Inhibitory Synapse Assembly
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Outflow Tract Septum Morphogenesis
Cell Adhesion
Axon Guidance
Positive Regulation Of Endothelial Cell Migration
Viral Process
Facial Nerve Structural Organization
Vestibulocochlear Nerve Structural Organization
Nerve Development
Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus
Ventral Trunk Neural Crest Cell Migration
Vascular Endothelial Growth Factor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Axon Extension Involved In Axon Guidance
Negative Chemotaxis
Sympathetic Ganglion Development
Trigeminal Ganglion Development
Sensory Neuron Axon Guidance
Sympathetic Neuron Projection Extension
Sympathetic Neuron Projection Guidance
Regulation Of Postsynapse Organization
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance
Facioacoustic Ganglion Development
Dorsal Root Ganglion Morphogenesis
Cellular Response To Leukemia Inhibitory Factor
Pathways
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
Neurophilin interactions with VEGF and VEGFR
NrCAM interactions
Drugs
Diseases
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Estimated glomerular filtration rate (
31152163
)
Inflammatory bowel disease (
28067908
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Blood protein levels (
30072576
29875488
)
Craniofacial microsomia (
26853712
)
Diisocyanate-induced asthma (
25918132
)
Neuropathy x type 2 diabetes interaction (
32541925
)
Interacting Genes
14 interacting genes:
ARHGEF11
ARHGEF12
KMT2A
L1CAM
MET
NRP1
NRP2
PLXNA1
RAC1
RND1
RND3
SEMA4B
SEMA4D
SOX4
11 interacting genes:
FLT1
L1CAM
NRP1
PGF
PLXNA1
PLXNB1
SEMA3B
SEMA3C
SEMA3F
SEMA4F
VEGFA
Entrez ID
5364
8828
HPRD ID
03032
03643
Ensembl ID
ENSG00000164050
ENSG00000118257
Uniprot IDs
O43157
O60462
Q7Z3T9
PDB IDs
2JPH
2OS6
2R2O
2REX
3HM6
3OL2
3SU8
3SUA
5B4W
2QQJ
2QQK
2QQL
2QQO
4QDQ
4QDR
4QDS
5DN2
5DQ0
6GH8
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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