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PLXNB1 and RND1
Data Source:
HPRD
(in vivo, in vitro)
PLXNB1
RND1
Description
plexin B1
Rho family GTPase 1
Image
GO Annotations
Cellular Component
Semaphorin Receptor Complex
Extracellular Region
Plasma Membrane
Integral Component Of Plasma Membrane
Cytosol
Cytoskeleton
Plasma Membrane
Adherens Junction
Cell Cortex
Actin Cytoskeleton
Cytoplasmic Vesicle
Cell Projection
Intracellular Membrane-bounded Organelle
Molecular Function
Transmembrane Signaling Receptor Activity
GTPase Activator Activity
Protein Binding
Semaphorin Receptor Activity
Semaphorin Receptor Binding
GTPase Activating Protein Binding
Signaling Receptor Activity
GTPase Activity
Signaling Receptor Binding
Protein Binding
GTP Binding
Protein Kinase Binding
Biological Process
Negative Regulation Of Cell Adhesion
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Regulation Of Cell Shape
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cell Migration
Regulation Of Cell Migration
Negative Regulation Of Osteoblast Proliferation
Intracellular Signal Transduction
Regulation Of GTPase Activity
Positive Regulation Of GTPase Activity
Ossification Involved In Bone Maturation
Neuron Projection Morphogenesis
Positive Regulation Of Axonogenesis
Regulation Of Cytoskeleton Organization
Semaphorin-plexin Signaling Pathway
Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis
Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Inhibitory Synapse Assembly
Actin Filament Organization
Negative Regulation Of Cell Adhesion
Establishment Or Maintenance Of Cell Polarity
Small GTPase Mediated Signal Transduction
Regulation Of Cell Shape
Neuron Remodeling
Cell Migration
Cortical Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Pathways
G alpha (12/13) signalling events
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Crohn's disease (
28067908
)
Estimated glomerular filtration rate (
31152163
)
Inflammatory bowel disease (
28067908
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Ulcerative colitis (
28067908
)
Bipolar disorder (
21926972
)
Interacting Genes
14 interacting genes:
ARHGEF11
ARHGEF12
KMT2A
L1CAM
MET
NRP1
NRP2
PLXNA1
RAC1
RND1
RND3
SEMA4B
SEMA4D
SOX4
23 interacting genes:
ARFIP2
ARHGAP5
CCNI
COPS2
CREB3L2
EEF1A1
FRS2
FRS3
GPX8
GRB7
ID3
MYH7
MYOM3
MYZAP
NEDD1
PAIP1
PDE6D
PLXNA1
PLXNB1
PLXNB2
RAI14
UBXN11
ZNF212
Entrez ID
5364
27289
HPRD ID
03032
12357
Ensembl ID
ENSG00000164050
ENSG00000172602
Uniprot IDs
O43157
Q92730
PDB IDs
2JPH
2OS6
2R2O
2REX
3HM6
3OL2
3SU8
3SUA
5B4W
2CLS
2REX
3Q3J
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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