SEMA4D and CD72

Data Source:
HPRD (in vivo, in vitro)

		SEMA4D	CD72
Description		semaphorin 4D	CD72 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Semaphorin Receptor Binding Signaling Receptor Activity Chemorepellent Activity	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Carbohydrate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Immune Response Cell Adhesion Negative Regulation Of Cell Adhesion Axon Guidance Regulation Of Cell Shape Negative Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Cell Migration Regulation Of Cell Projection Organization Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Ossification Involved In Bone Maturation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Leukocyte Aggregation Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Positive Regulation Of Inhibitory Synapse Assembly	Cell Adhesion
Pathways		Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Other semaphorin interactions	Other semaphorin interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 28296344) Brain morphology (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Youthful appearance (self-reported) ( 32339537)	Blood protein levels ( 30072576) Electroencephalogram traits ( 25387704)
Interacting Genes		5 interacting genes: CD72 CRK LINC00839 PLXNB1 PTPRC	22 interacting genes: ATP6AP2 BIK BLNK CD5 CGRRF1 CLDN7 CREB3L1 GPR152 GRAMD1C GRB2 LHFPL5 LMNA LRRC25 LSMEM2 LYN MS4A3 MS4A7 NRG1 PTPN6 SEMA4D SPACA1 SYK
Entrez ID		10507	971
HPRD ID		03520	00118
Ensembl ID		ENSG00000187764	ENSG00000137101
Uniprot IDs		Q92854	P21854 Q5TLG3
PDB IDs		1OLZ 3OL2
Enriched GO Terms of Interacting Partners?
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