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SEMA4D
Description
semaphorin 4D
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Signaling Receptor Binding
Protein Binding
Semaphorin Receptor Binding
Signaling Receptor Activity
Chemorepellent Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Neural Crest Cell Migration
Positive Regulation Of Protein Phosphorylation
Immune Response
Cell Adhesion
Negative Regulation Of Cell Adhesion
Axon Guidance
Regulation Of Cell Shape
Negative Regulation Of Alkaline Phosphatase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Cell Migration
Regulation Of Cell Projection Organization
Negative Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Ossification Involved In Bone Maturation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Collateral Sprouting
Regulation Of Dendrite Morphogenesis
Negative Regulation Of Axon Extension Involved In Axon Guidance
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Chemotaxis
Leukocyte Aggregation
Semaphorin-plexin Signaling Pathway
Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis
Positive Regulation Of Inhibitory Synapse Assembly
Pathways
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
Other semaphorin interactions
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Body mass index (
28296344
)
Brain morphology (MOSTest) (
32665545
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
5 interacting genes:
CD72
CRK
LINC00839
PLXNB1
PTPRC
Entrez ID
10507
HPRD ID
03520
Ensembl ID
ENSG00000187764
Uniprot IDs
Q92854
PDB IDs
1OLZ
3OL2
Enriched GO Terms of Interacting Partners
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