TAB1 and POLDIP2

Data Source:
BioGRID (two hybrid)

		TAB1	POLDIP2
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 1	DNA polymerase delta interacting protein 2
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GO Annotations	Cellular Component	Nucleus Cytosol Endosome Membrane Nuclear Speck Protein-containing Complex	Nucleus Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid
	Molecular Function	Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Enzyme Activator Activity Kinase Activator Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase P38 Binding	DNA Binding Protein Binding
	Biological Process	Activation Of MAPKKK Activity Activation Of MAPK Activity In Utero Embryonic Development Stimulatory C-type Lectin Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Heart Morphogenesis Cardiac Septum Development Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Protein Deubiquitination Lung Development Aorta Development Fc-epsilon Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Coronary Vasculature Development Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Macroautophagy Positive Regulation Of Mitotic Cell Cycle Mitochondrion Morphogenesis Error-free Translesion Synthesis
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs		Manganese
Diseases
GWAS		Factor VIII levels ( 30586737) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Schizophrenia ( 29483656) Sleep duration (short sleep) ( 30846698) vWF levels ( 30586737) Waist circumference ( 28552196)	Blood protein levels ( 29875488) Osteoprotegerin levels ( 25080503)
Interacting Genes		74 interacting genes: AATK ACAP3 ARAP1 ASRGL1 BMPR1A C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A DBN1 DVL2 EGFR EPRS1 ERBB4 FADD FN1 GIT1 HNRNPR IKBKG ITCH KIFC2 LAP3 LCMT1 LGALS7 LGALS7B LNX2 MAP3K1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 ROR2 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SMURF1 SNRNP35 TAB2 TAB3 TRAF2 TRAF6 TRIP6 TRPC4AP TSSC4 UBC URB1 WDCP WTAP XIAP XPO7 YWHAG ZMYND11	19 interacting genes: AGTRAP ALAS1 APP ASCC2 CHCHD2 CPE DNAAF6 FBXO7 HDAC6 MAD2L2 MTUS2 PCNA PDPK1 POLD2 POLN PTEN REV1 SELENBP1 TAB1
Entrez ID		10454	26073
HPRD ID		04012	17874
Ensembl ID		ENSG00000100324	ENSG00000004142
Uniprot IDs		A8K6K3 Q15750	B4DEM9 Q9Y2S7
PDB IDs		2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L52 4L53 4O91 5DIY 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5NZZ 5O90 5V5N 5VVU	6Z9C
Enriched GO Terms of Interacting Partners?
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